Some Properties of Diazepam-Polyethylene Glycol 6000 Solid Dispersions and their Modification in the Presence of Stearic Acid of Polysorbate 80

Amorphous drug substances

“…Metodę stapiania stosowano m.in. do amorfizacji desloratadyny [25], nimodypiny [26], diazepamu [27] [29]. Amorfizację nimodypiny oraz diazepamu uzyskano w przypadku stałych rozproszeń sporządzonych z makrogolem 4000 oraz 6000.…”

A factor analysis for complex systems containing nimesulide

“…In the first part of the study only binary systems were prepared as physical mixtures and as solid dispersions by comelting method, and examined their morphological aspect, crystallinity and release characteristics, concerning drug dissolution. Because on cooling the systems displayed an evident phase separation, in a second step ternary systems were considered, adding to previous systems either surfactants, or a basic substance with the aim to avoid this phenomenon 22–24…”