Some Problems in the Pathology of Syphilis

Fordyce, John A.

doi:10.1097/00000441-191506000-00001

Cited by 17 publications

(3 citation statements)

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“…Testing for syphilis had been introduced after the first cases of transfusion‐transmitted syphilis, from a brother to his sister, was reported by Fordyce, . Blood was collected into effective but voluminous ‘preservative/anticoagulant’ solutions of sodium citrate with added glucose (1.2 L to 500 mL blood).…”

Section: Preserved Blood and Major Oswald Robertsonmentioning

confidence: 99%

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Boulton

Roberts

2014

Transfusion Medicine

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The centenary of the start of the First World War has stirred considerable interest in the political, social, military and human factors of the time and how they interacted to produce and sustain the material and human destruction in the 4 years of the war and beyond. Medical practice may appear distant and static and perhaps seems to have been somewhat ineffectual in the face of so much trauma and in the light of the enormous advances in medicine and surgery over the last century. However, this is an illusion of time and of course medical, surgical and psychiatric knowledge and procedures were developing rapidly at the time and the war years accelerated implementation of many important advances. Transfusion practice lay at the heart of resuscitation, and although direct transfusion from donor to recipient was still used, Geoffrey Keynes from Britain, Oswald Robertson from America and his namesake Lawrence Bruce Robertson from Canada, developed methods for indirect transfusion from donor to recipient by storing blood in bottles and also blood-banking that laid the foundation of modern transfusion medicine. This review explores the historical setting behind the development of blood transfusion up to the start of the First World War and on how they progressed during the war and afterwards. A fresh look may renew interest in how a novel medical speciality responded to the needs of war and of post-war society.

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Section: Preserved Blood and Major Oswald Robertsonmentioning

confidence: 99%

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Boulton

Roberts

2014

Transfusion Medicine

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“…Since transfusion-related syphilis was first described in 1915 [1], reports of over 200 cases in total have been published [15,18]. Early studies reported in 1941 on 138 cases documented up to that date, but the authors presumed that the number of unreported cases was very high.…”

Section: Prevalence and Incidence Of Blood-associated Infections And mentioning

confidence: 99%

Treponema pallidum

2003

Transfus Med Hemother

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“…Syphilis has been transmitted via contaminated blood transfusions, [8][9][10][11][12][13][14][15][16] which has prompted routine serologic screening by blood banks. However, experiments have demonstrated that Treponetna pallidurn does not survive more than a few days under present blood banking conditions.12.…”

mentioning

confidence: 99%

Survival of Borrelia burgdorferi in human blood stored under blood banking conditions

Nadelman¹,

Sherer

Mack

et al. 1990

Transfusion

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Hematogenous dissemination of organisms occurs in many spirochetal diseases, including Lyme disease and syphilis. Although syphilis has been transmitted by transfusion, in the vast majority of cases, only fresh blood products were involved, in part because Treponema pallidum survives poorly when refrigerated in citrated blood. Because of the rising incidence of Lyme disease in certain areas, whether its causative agent, Borrelia burgdorferi, could survive under blood banking conditions was studied. Dilutions of stock cultures of two strains of B. burgdorferi were inoculated into samples of citrated red cells (RBCs). Viable spirochetes were recovered from RBCs inoculated with 10(6) organisms per mL, after refrigeration for as long as 6 weeks. It is concluded that B. burgdorferi may survive storage under blood banking conditions and that transfusion-related Lyme disease is theoretically possible.

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Some Problems in the Pathology of Syphilis

Cited by 17 publications

References 0 publications

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Treponema pallidum

Survival of Borrelia burgdorferi in human blood stored under blood banking conditions

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