Some Problems in Dietary Amino Acid Requirements

Dietary therapy in a girl with propionic acidemia: Supplement with leucine resulted in catch up growth.

“…Leucine is one of the essential amino acids and the amount of its daily requirement in infancy is considered to be larger than other amino acids (Holt 1968). However, it was reported that leucine was one of the amino acids noxious to a child with propionic acidemia (Chills et al 1961) and in a dietary management, a diet restricted of not only amino acids which are in vivo convertable to propionylCoA but also leucine was devised (Nyhan 1967;Brandt et al 1974).…”

Premiers essais de nutrition artificielle chez les Mugilidae

“…Numerous studies have shown that protein nitrogen is not absolutely necessary for the rat (ADKINS et al 1967) or for man (HOLT 1968): urea nitrogen can maintain normal rates of growth and of nitrogen retention. Mugil capito of an average wet weight of 800 mg were kept without food in urea solutions of increasing concentrations (2, 4 and 8 g/1 seawater).…”

Dietary therapy in two patients with vitamin B12-unresponsive methylmalonic acidemia

“…On these regimens, the levels of urinary MMA were between 7.6 and 13.9mg/mg of creatinine in case 1 and between 1.8 and 5.5 mg/mg ofcreatinine in case 2, and both patients showed no ketoacidosis. The amounts of valine, isoleucine, threonine and methionine in these formulas bordered on or were below the minimal daily requirement (Holt 1968), especially in case 2. However, these patients displayed physical and mental development, and no symptoms suggestive of protein malnutrition such as failure to thrive, change in hair colour, loss of hair, skin pigmentation, or edema associated with hypoalbuminemia were observed.…”