Some principles and practices of genetic biobanking studies

MacLeod, Andy; Liewald, David C.; McGilchrist, Mark; Morris, Andrew D.; Kerr, Shona M.; Porteous, David J.

doi:10.1183/09031936.00043508

Cited by 14 publications

(15 citation statements)

References 22 publications

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“…There is evidence to show that despite the recent increase in media publicity about genetic research, the level of knowledge in patients with chronic diseases such as asthma has not undergone a parallel increase [7]. Important aspects regarding this are discussed by MACLEOD et al [1], including data confidentiality, consent and reporting of results to patients. Genetic testing has given rise to other issues such as the possibility of stigma and challenging cultural and social attitudes.…”

Section: The Phenotype and Genotype In Osahsmentioning

confidence: 99%

“…In the first paper of the series, MACLEOD et al [1] demonstrate that when studying genetic aspects of complex diseases such as hypertension and OSAHS, good sample and data management is necessary to ensure that the data collected are stored accurately and efficiently, and passed through the process of analysis in an orderly manner. In order to be able to collect information on a complex trait, increasingly larger cohorts are required for adequate power and subsequent replication of findings.…”

Section: Design Of Genetic Studies In Cardiovascular Disease and Osahmentioning

confidence: 99%

“…Genetic biobanking is becoming increasingly prevalent and the principles of storage of data as well as the ethical issues associated with it are described in detail. MACLEOD et al [1] use the example of the Generation Scotland project, which has been successfully run for the last 5 yrs with its centre located in Edinburgh (UK).…”

Section: Design Of Genetic Studies In Cardiovascular Disease and Osahmentioning

confidence: 99%

“…An upcoming series that will be published over the next 6 months in the European Respiratory Journal (ERJ), presents some of the key papers from the symposium. The first paper in the series, by MACLEOD et al [1], introduces the importance of meticulous design, data collection and storage in studies of complex disease, using the example of Generation Scotland. The paper serves as the background for further contributions to the series, which continue with a discussion of the difficulties in phenotyping and, by inference, the difficulties inherent to genotyping such a complex disorder as OSAHS [2].…”

mentioning

confidence: 99%

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The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome

Riha¹,

McNicholas²

2008

European Respiratory Journal

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Section: The Phenotype and Genotype In Osahsmentioning

confidence: 99%

Section: Design Of Genetic Studies In Cardiovascular Disease and Osahmentioning

confidence: 99%

Section: Design Of Genetic Studies In Cardiovascular Disease and Osahmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome

Riha¹,

McNicholas²

2008

European Respiratory Journal

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“…The registration of each sample entering and exiting the bio-bank is centrally controlled and managed by a software that must be backed up frequently [65] The labeling, registration and physical location of each sample, as well as its identifycation data, quantity, type of resource are link to a bar- code and barcode reader system to allow the rapid tracking and position and quantity of the specimen. As for biological point of view, optimization of protocols for cryoconservation, definition of best practice and standard operating procedures, bio-safety, and a temperature system control must be defined.…”

Section: Bio-banks and Digital Preservationmentioning

confidence: 99%

Conservation of endangered animals: From biotechnologies to digital preservation

Pizzi¹,

Caroli²,

Landini³

et al. 2013

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In the recent years, the number of endangered animals, both referred to livestock and wild species, has grown enormously. The "livestock" term refers to animals domesticated for producing commodities for man such as food, fiber and draught. Livestock biodiversity is integral to our culture, history, environment, and economy. Thousands of livestock breeds have evolved over time to suit particular environments and farming systems. Conservation and analyses of these genetic resources rely on demographic characterization and correct breeding schemes. In addition, molecular genetic studies allow to identify and monitor the genetic diversity within and across breeds and to reconstruct their evolution history. The conservation of livestock variability is also a crucial element in order to preserve and valorise specific nutritional and nutraceutical properties of animal products. Efficient ex situ and in situ conservation strategies, as well as the creation of bio-banks and specific biotechnological and bioinformatics tools for genetic analyses and digital preservation, are obligatory requirements in order to implement an appropriate action for the conservation of animal biodiversity. The main issues concerning different species are summarised, with particular reference to the livestock biodiversity still existing. Some examples of ex situ conservation strategies, which mainly refer to cryoconservation of semen, ova, embryos or tissues, developed in Italy, are presented, and the different actions in defense of Animal Genetic Resources (AnGR) developed within the European Community are illustrated. Interestingly, the same strategies for biological and digital analyses and preservation of livestock biodiversity can be exported to wild endangered animals in order to plan a correct conservation and repopulation of the species. Furthermore, the European Union has set up the guidelines to safeguard the biodiversity and to combat the extinction of animal species, and has made the protection of biodiversity and ecosystems one of the main objectives of the Sixth Environment Action Programme.

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Laboratory/Pathology Services and Blood Bank

Fleming

Klammer

Koh

2021

The Comprehensive Cancer Center

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Pathology and its laboratories are central in support of every facet of cancer care in a CCC center, from diagnosis, to patient support during treatment, research, therapeutic drug manufacture and development and bio-banking.We have approached this discussion from the perspective of the timeline of a patient’s journey through cancer care. We begin with screening programs, high quality diagnostics and then maintaining quality supportive cancer care. Specialised services such as cellular therapies and haematopoietic stem cell transplantation with their unique requirements are considered and lastly we discuss the vital role of clinical trials and research in comprehensive cancer care with a focus on biobanks.We also examine the role of the diagnostic laboratories and their clinical and scientific staff in shaping an integrated cancer diagnostic report, as an integral part of a cancer Multidisciplinary Team (MDT) or “Tumour Board”. Increasingly, integration of a large amount of clinical data, laboratory results and interpretation of complex molecular and genomic datasets is required to underpin the role of CCC’s as centres of clinical excellence and to collaborate with partners in local, national and international research protocols.

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Some principles and practices of genetic biobanking studies

Cited by 14 publications

References 22 publications

The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome

The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome

Conservation of endangered animals: From biotechnologies to digital preservation

Laboratory/Pathology Services and Blood Bank

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