Some Preliminary Findings on the Nutritional Status of the Aged in Onondaga County, New York

Brin, Myron; Dibble, Marjorie V.; Peel, Annette; McMullen, Elsa A.; Bourquin, Anne; Chen, Nancy; Braddon, Sylvia; Rogers, Mariba; Buren, Norma Van; Holden, Dorcas

doi:10.1093/ajcn/17.4.240

Cited by 95 publications

(26 citation statements)

References 14 publications

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“…In the previous study on patients with advanced malignant disease, 46 % of 38 patients had TPP values over ten. Other workers [Brin et al 1965; C hong and Ho] have claimed that only values for the TPP effect over 25 % should be considered Meon t-5 10-2 11-5 SEM 1-9 1-8 2-6 Figure 1. Effect of adding thiamin pyrophosphate (TPP effect) on the transketolase activity of the whole blood of patients with early bronchial and breast carcinomas.…”

Section: Resultsmentioning

confidence: 99%

The Thiamin Status of Early Cancer Patients with Particular Reference to Those with Breast and Bronchial Carcinomas

Basu¹,

Dickerson²

1976

Oncology

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The thiamin status of early bronchial and breast carcinomas has been assessed using “thiamin pyrophosphate” (TPP) stimulating effect of transketolase enzyme activity. The TPP stimulating effect was found to be greater in a high proportion of the cancer patients than in normal subjects, suggesting that these patients may be at risk of thiamin deficiency. The urinary excretory level of thiamin was high in the cancer patients; it is, therefore, unlikely that the biochemical deficiency of the vitamin was due to lack of the vitamin intake. It is, however, possible that the cancer patients were unable to convert thiamin to thiamin pyrophosphate, the active form of the vitamin.

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Section: Resultsmentioning

confidence: 99%

The Thiamin Status of Early Cancer Patients with Particular Reference to Those with Breast and Bronchial Carcinomas

Basu¹,

Dickerson²

1976

Oncology

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“…The next collection of data was made between February 26 and May 25, 1965 on 112 subjects who were designated the “Spring” group. A portion of the Fall data has been reported previously (1) but it will be repeated in this paper with additional material, for purposes of a comparison by seasons. Among the 214 apartment‐living residential subjects in the total study, there were 46 subjects who were in both groups; they will be referred to as the “Control” group.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Nutritional Status of Elderly Subjects, With a Comparison Between Fall and Spring*

Dibble

Brin

Thiele

et al. 1967

J American Geriatrics Society

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“…The haemolyzed whole blood was used to mea sure the activity of the enzyme transketolase (TK) which has been reported to be a sensitive and spe cific method for assessing the thiamin status [Brin et al, 1965], The TK enzyme activity was mea sured according to the simplified method de scribed by Basu et al [1974b]. As low TK activity may result from a lack of the enzyme cocarboxy lase which is derived from thiamin [Breslow, 1962], the TK activity was also measured in the presence of added thiamin pyrophosphate (TPP).…”

Section: Study IImentioning

confidence: 99%

“…As low TK activity may result from a lack of the enzyme cocarboxy lase which is derived from thiamin [Breslow, 1962], the TK activity was also measured in the presence of added thiamin pyrophosphate (TPP). The TK activity was expressed as the number of /<mols of £>-sedohcptulosc-7-phosphate formed in itially at 37 °C, per minute per millilitre haemo lyzed whole blood, while any enhancement of the enzyme activity, which resulted from the added TPP, was expressed as a percentage of the original activity and referred to as the 'TPP effect' [Brin et al, 1965],…”

Section: Study IImentioning

confidence: 99%

Effects of 5-Fluorouracil on the Thiamin Status of Adult Female Rats

Basu¹,

Aksoy²,

Dickerson³

1979

Chemotherapy

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The effect of 5-fluorouracil on the thiamin status of normal female adult rats has been investigated. Pre-treatment of the animals with the cytotoxic drug daily for 3 successive days resulted in a significant decrease in hepatic concentrations of thiamin concomitant with a decrease in thiamin-dependent transketolase enzyme activity and an increase in thiamin-pyrophosphate-(TPP-)stimulating effect in whole blood when compared with those of pair-fed control animals. The TPP effect of transketolase enzyme activity was also increased by 5-fîuorouracil in vitro. Furthermore, the treatment with 5-fluorouracil resulted in decreased liver and spleen concentrations without affecting the urinary excretory levels of thiamin in animals supplemented with large doses of the vitamin. Giving a dose comparable to a human therapeutic dose caused a similar increase in the TPP effect. These results indicate that treatment with 5-fluorouracil may be associated with thiamin deficiency by increasing either the utilization or the breakdown of thiamin.

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Some Preliminary Findings on the Nutritional Status of the Aged in Onondaga County, New York

Cited by 95 publications

References 14 publications

The Thiamin Status of Early Cancer Patients with Particular Reference to Those with Breast and Bronchial Carcinomas

The Thiamin Status of Early Cancer Patients with Particular Reference to Those with Breast and Bronchial Carcinomas

Evaluation of the Nutritional Status of Elderly Subjects, With a Comparison Between Fall and Spring*

Effects of 5-Fluorouracil on the Thiamin Status of Adult Female Rats

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