Some possibilities for prostaglandin mediation in the contractile response to ATP of the guinea-pig digestive tract

Kamikawa, Yuichiro; Serizawa, K.; Shimo, Yasuo

doi:10.1016/0014-2999(77)90090-5

Cited by 33 publications

(15 citation statements)

References 9 publications

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“…Thus, the present findings suggest that the tonic ATP response is produced by prostaglandins. Kamikawa, Serizawa & Shimo (1977) showed a similar effect of indomethacin on 'rebound' contraction to exogenous ATP of longitudinal muscles of the guinea-pig digestive tract. Burnstock, Cocks, Paddle & StaszewskaBarczak (1975) found a total inhibition by indomethacin of the 'rebound' contraction following stimulation of non-adrenergic, non-cholinergic ('purinergic') inhibitory nerves in guinea-pig taenia coil.…”

Section: Resultsmentioning

confidence: 68%

Contribution of Prostaglandins to the Adenosine Triphosphate‐induced Contraction of Rabbit Urinary Bladder

Andersson

Husted

Sjögren

1980

British J Pharmacology

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1 Adenosine 5'-triphosphate (ATP) produced an inital rapid, phasic contraction and a later, slowly developing tonic contraction in the isolated detrusor of the rabbit but mainly a rapid, phasic response in the guinea-pig bladder.2 Electrical field stimulation elicited only a rapid, phasic contraction in both rabbit and guinea-pig bladders. 3 Prostaglandin synthesis inhibition by means of indomethacin and suprofen abolished the tonic response to ATP in the rabbit detrusor, leaving the phasic part of the contraction almost unaffected. The ATP-induced contraction in guinea-pig bladder was not influenced by indomethacin.4 The contractile response of rabbit urinary bladder to prostaglandins F2, and E2 and to carbachol were not significantly influenced by indomethacin. The contractions induced by the prostaglandins were similar to the tonic response to ATP. 5 Tetrodotoxin, atropine, phentolamine, and theophylline did not alter the ATP-induced contraction. However, the calcium antagonists, nifedipine and nimodipine, abolished the phasic ATP response and greatly reduced the tonic part of the contraction. 6 Tachyphylaxis occurred on repeated addition of ATP; the response to field stimulation was progressively reduced only after indomethacin pretreatment. 7 ATP and prostaglandins may contribute to the non-adrenergic, non-cholinergic component of the excitation of rabbit and guinea-pig bladder.

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Section: Resultsmentioning

confidence: 68%

Contribution of Prostaglandins to the Adenosine Triphosphate‐induced Contraction of Rabbit Urinary Bladder

Andersson

Husted

Sjögren

1980

British J Pharmacology

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“…Complete recovery of muscle responsiveness to both purines was observed after prolonged washing (30-50 min) in all preparations tested (n= 12). A prostaglandin-mediated contraction of intestinal smooth muscle in response to ATP has been iooo described (Burnstock, Cocks, Paddle & StaszewskaBarczak, 1975;Kamikawa et al, 1977 administrations of the latter compound. In the pres-0 ence of indomethacin after-contractions were never observed.…”

Section: Methodsmentioning

confidence: 99%

“…An advantage of including adenosine in the study is that this compound possesses only some of the properties typical of ATP. Pharmacological actions of ATP not shared by adenosine include the induction of prostaglandin biosynthesis (Needleman, Minkes & Douglas, 1974;Kamikawa, Serizawa & Shimo, 1977), the chelation of Ca2+ ions (Kahn & Martell, 1962;Daniel, 1965) and the ability to provide energy by rapid degradation of the polyphosphate.…”

Section: Introductionmentioning

confidence: 99%

Effects of Desensitization to Adenosine 5′‐triphosphate and Adenosine on Non‐adrenergic Inhibitory Responses in the Circular Muscle of Rabbit Colon

Crema

D’Angelo

Frigo

et al. 1982

British J Pharmacology

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1 An approximate eight fold desensitization of the circular coat of the distal rabbit colon to adenosine 5'-triphosphate (ATP) and adenosine could be achieved by repeatedly exposing the organ to relatively low concentrations (10-100 pM) of these compounds.2 The desensitization was specific and reversible after prolonged washing. It could be overcome by increasing the concentrations of the purine agonists. 3 Dipyridamole potentiated the non-adrenergic inhibition in response to transmural stimulation but failed to influence the caudad relaxation evoked by radial distension. 4 Desensitization to ATP and adenosine (and to ATP + adenosine simultaneously) did not affect the non-adrenergic inhibition in response to radial distension or transmural stimulation. 5 These results suggest that neither ATP nor adenosine are the final transmitters mediating the non-adrenergic inhibitory responses in the distal colon of the rabbit.

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“…In the rat esophageal muscularis mucosae, however, serotonin did not produce a contraction but relaxed the cholinergically-induced tone via the stimulation of postjunctional 5-HT4 receptor which was coupled to the adenylate cyclase-cyclic AMP pathway (Baxter et al, 1991;Moummi et al, 1992;Ford et al, 1992;Ohia et al, 1992;Yang et al, 1993;Leung et al, 1996;Goldhill et al, 1997). Adenosine and related purine nucleotides also enhanced cholinergic neurotransmission by the postjunctional mechanism, since the purine nucleotides produced a contraction of the muscularis mucosae via the production of endogenous PGs, probably PGE2 (Kamikawa et al, 1977;. Muscularis mucosae is a major source for PGs production in the digestive tracts (Lawson and Powell, 1987).…”

Section: Responsiveness To Drugsmentioning

confidence: 99%

Muscularis mucosae - the forgotten sibling

Uchida

Kamikawa

2007

J. Smooth Muscle Res.

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Lamina muscularis mucosae sitting beneath mucosal surface of the digestive tract has received little attention to date compared with external smooth muscle layers. Motor activity of the muscularis mucosae shows a great regional and species difference. Autonomic innervation profile is also different from esophagus to colon or between animal species. Intracellular transduction mechanisms for motor activity of the muscularis mucosae are also different from those of external longitudinal and circular muscles or from vascular and airway smooth muscles. Since the submucosal area is a major source for eicosanoid production, abnormality of muscularis mucosae motor activity may link with abnormality of mucosal absorption and secretion functions. Inflammatory bowel diseases such as diarrhea, irritable bowel syndrome and Crohn's disease accompanied with altered motor activity of the muscularis mucosae. Much attention should be attracted to the human muscularis mucosae as a new therapeutic target for inflammatory bowel diseases.

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Some possibilities for prostaglandin mediation in the contractile response to ATP of the guinea-pig digestive tract

Cited by 33 publications

References 9 publications

Contribution of Prostaglandins to the Adenosine Triphosphate‐induced Contraction of Rabbit Urinary Bladder

Contribution of Prostaglandins to the Adenosine Triphosphate‐induced Contraction of Rabbit Urinary Bladder

Effects of Desensitization to Adenosine 5′‐triphosphate and Adenosine on Non‐adrenergic Inhibitory Responses in the Circular Muscle of Rabbit Colon

Muscularis mucosae - the forgotten sibling

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