Some Physiological, Biochemical, and Morphologic Effects of Tris (p-Aminophenyl) Carbonium Salts (TAC) on Schistosoma Mansoni *

Bueding, Ernest; Schiller, Everett L.; Bourgeois, John G.

doi:10.4269/ajtmh.1967.16.500

Cited by 60 publications

(22 citation statements)

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“…[1][2][3][4][5][6][10][11][12][13][14][15][16] Machos alongados, com acentuada cur vatura ventral, medem 6,65 a 12 mm de comprimento. P arte anterior do corpo cur ta e m ais ou menos cilíndrica, onde se en contram as ventosas oral e ventral.…”

Section: Methodsunclassified

Estudo morfológico do Schistosoma mansoni Sambon, 1907 encontrado na espécie humana

Kastner

Kohn

Teixeira³

1975

Rev. Soc. Bras. Med. Trop.

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Nosso trabalho refere-se ao estudo do Schistosoma m ansoni Sambon, 1907, obtido por filtração extracorpórea de pacientes crônicos, portadores de hipertensão porta com indicação cirúrgica, trazendo assim mais um a contribuição ao conhecimento deste parasito. MATERIAL E MÉTODOSCinco pacientes portadores de equistos-.somose m ansoni com 'hipertensão portal foram levados à cirurgia de desccmpressão seletiva de varizes de esôfago (42) (Tab. I). Com plementando a cirurgia, foi realizada filtração extra-corpórea através da veia esplênica ou m esentérica inferior, usando-se um a bomba de perfusão de Rim Artificial. Notas do exame macroscópico foram tom a das e exemplares de tecidos do paciente fo ram fixados em formol neutro a 10% para seu estudo histopatológico.Os vermes obtidos foram fixados com formol neutro a 10%. P arte deles foi sepa rada e corada pelo carmim clorídrico al coólico, desidratada n a série alcoólica, diafanizada com fenol e creosoto de faia, e m ontada em bálsamo do Canadá. Outra parte dos vermes foi incluída n a parafina e feitos cortes seriados de 5n, que foram co rados pela hem atoxilina eosina e pelo tricrômico de Gomori.Finalm ente, com o intuito de estudar a distribuição dos constituintes celulares, cortes seriados foram corados com técnicas histoquímicas simples: PAS, com controle de amilase p ara o estudo de carbohidratos e glicogênio; Brachet, com controle de ri-* I n s t i t u t o O sw aldo C ru z, D e p a rta m e n to de P a to lo g ia e D oenças T ro p icais e Z ;o lo g ia M édica Caixa P o sta l 926 -ZC-00 -20.000 -R io d e J a n e iro -B rasil. ** P e sq u is a d o r em B iologia do M in isté rio d a S aú d e, (I.O .C .); P e sq u isa d o r do C onselho N acional de P esq u isas. *** P ro fesso r A ssiste n te d a F a c u ld a d e de M e d icin a e C iru rg ia do E lo de Ja n e iro . ***» C h efe d o S erviço de C iru rg ia do H o sp ita l São V icen te de P a u la . G o v ern ad o r V aladares M inas G erais. R eceb id o p a r a p u b lic a ç ã o em 14.7.75.

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Section: Methodsunclassified

Estudo morfológico do Schistosoma mansoni Sambon, 1907 encontrado na espécie humana

Kastner

Kohn

Teixeira³

1975

Rev. Soc. Bras. Med. Trop.

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“…In schistosomes only a small proportion of their total proteins is contributed by the nervous tissue where AChE is predominantly, if not exclusively, located (Bueding et al, 1967). Since the activity of schistosome AChE per mg of protein approaches that of mammalian nervous tissue (mouse brain), the activity of this enzyme in the nervous structures of these trematodes must certainly be of a high order.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, a subsequent return of enzyme activity was associated with a return of the worms to the mesenteric veins. Since there is evidence for a physiological role of acetylcholine in schistosomes (Bueding, 1952;Barker et al, 1966) and since administration of another antischistosomal compound, i.e., p-rosaniline, results in an inhibition of AChE activity of S. mansoni (Bueding et al, 1967), it is possible that AChE inhibition produces functional damage to the worm.…”

Section: Discussionmentioning

confidence: 99%

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Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Bueding

Liu

Rogers

1972

British J Pharmacology

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Summary1. No species differences between Schistosoma haematobium and Schistosoma mansoni were detected when the 150 of metrifonate for the acetylcholinesterases (AChE) and the cholinesterases (ChE) of these two trematodes were determined in isolated enzyme preparations or following exposure of the intact worms to this drug in vitro. 2. S. haematabium appeared to be more affected by AChE inhibition because, after administration of metrifonate to hamsters, a hepatic shift of the parasites was observed with a dose of metrifonate (150 mg (0-6 mmol) per kg) which produced no shift of S. mansoni, although AChE inhibition was comparable in both species. 3. Administration of a possible metabolite of metrifonate, dichlorvos, to hamsters resulted in a greater inhibition of AChE and ChE activities of S. haematobium than those of S. mansoni. Furthermore, when schistosomes were incubated with dichlorvos, inhibition of AChE activity of female S. haematobium was significantly greater (P<0 005) than that of both sexes of S. mansoni and of male S. haematobium. 4. The discrepancy between the lack of a significant chemotherapeutic effect of metrifonate in hamsters infected with S. haematobium and the clinical results obtained with this organophosphorus compound in human schistosomiasis haematobium is discussed, and the need to conduct similar studies in primates is pointed out.

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“…Acetylcholinesterase localizations, according to the method of Bueding, Schiller, and Bourgeois (1967), were used to determine nervous system morphology.…”

Section: Methodsmentioning

confidence: 99%

Biology of aspidobothrian trematodes

Fredericksen

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Some Physiological, Biochemical, and Morphologic Effects of Tris (p-Aminophenyl) Carbonium Salts (TAC) on Schistosoma Mansoni *

Cited by 60 publications

References 0 publications

Estudo morfológico do Schistosoma mansoni Sambon, 1907 encontrado na espécie humana

Estudo morfológico do Schistosoma mansoni Sambon, 1907 encontrado na espécie humana

Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Biology of aspidobothrian trematodes

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