1983
DOI: 10.1016/0378-8741(83)90037-5
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Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala

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Cited by 72 publications
(43 citation statements)
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“…The extract was administered by gavage at the doses of 1000, 2000, 4000, 8000, 10,000, 12,000 and 14,000 mg/ kg or by the intraperitoneal route at the doses of 100, 250, 500, 1000, 2000, 4000 and 8000 mg/kg. The general behavior of mice was observed continuously for 1 h after the treatment and then intermittently for 4 h, and thereafter over a period of 24 h (Twaij et al, 1983). The mice were further observed for up to 14 days following treatment for any signs of toxicity and death, and the latency of death.…”
Section: Acute Toxicity Studiesmentioning
confidence: 99%
“…The extract was administered by gavage at the doses of 1000, 2000, 4000, 8000, 10,000, 12,000 and 14,000 mg/ kg or by the intraperitoneal route at the doses of 100, 250, 500, 1000, 2000, 4000 and 8000 mg/kg. The general behavior of mice was observed continuously for 1 h after the treatment and then intermittently for 4 h, and thereafter over a period of 24 h (Twaij et al, 1983). The mice were further observed for up to 14 days following treatment for any signs of toxicity and death, and the latency of death.…”
Section: Acute Toxicity Studiesmentioning
confidence: 99%
“…Median lethal dose (LD 50 ) was evaluated by the Karber method. 17 The animals were executed after the examination was finished.…”
mentioning
confidence: 99%
“…In contrast to the above mentioned positive effects, all the following plant extracts (Ditrichia graveolens, Alkanna strigosa, Sinapis arvensis, Centaurea iberica, Asphodelin lutea, Paronychia argentea, rosmarinus officinalis, Achillea santolina, Achillea micrantha, Allium sativum, Centaurea phyllacephala, Centaurea behen, Crataegus azarolus failed to produce a significant hypoglycemic or hyperglycemic effects. Some produced slight hyperglycemic effects or mild elevation in the plasma glucose levels (AI-Khazarji et al, 1993;Twaij et al, 1989;Al-Shamaony et al, 1994;Twaij et al, 1983;Twaij et al, 1987b;Twaij et al, 1988a & b), in comparison with effects obtained from the controls. On the other hand, Myrtus communis and Prosopis farcta produced a significant hyperglycemic activity at 90 min compared to zero time.…”
Section: Anti-diabetic and Hypoglycemic Studymentioning
confidence: 99%