Some pharmacological effects of the ethanol extract of leaves ofAnnona diversifolia on the central nervous system in mice

González-Trujano, Ma. Eva; Navarrete, Andrés; Reyes, Beverly A.S.; Hong, Enrique

doi:10.1002/(sici)1099-1573(199812)12:8<600::aid-ptr363>3.0.co;2-n

Cited by 45 publications

(37 citation statements)

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“…The time each animal remained on the rod (''time-on-rod'') was recorded every 10 min for a total recording of 120 min. Effect on motor coordination was considered when mice remained on the rod for less than 2 min (González-Trujano et al, 1998).…”

Section: Effect On Motor Coordination On Rota-rod Testmentioning

confidence: 96%

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Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice

Balderas-López

Alfaro-Romero

Monroy

et al. 2013

Pharmaceutical Biology

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Results: Crude extracts of T. sylvatica fruits, separated from seed and pericarp, showed sedative effect in mice. The aqueous (ED 50 ¼ 4.9 AE 0.8 mg/kg) seed extracts is the most active among them. This extract also decrease locomotor activity and disrupt motor coordination of mice. This extract was also the most toxic extract (LD 50 ¼ 5.0 AE 1.4 mg/kg; i.p.). The triterpene glycoside 28-O-[b-L-6-rhamnopyranosyl]-R 1 -barrigenol was identified in this extract as one of the active sedative compounds (ED 50 ¼ 0.12 AE 0.01 mg/kg) also with toxic effect (LD 50 ¼ 1.11 AE 0.23 mg/kg). Conclusion:The results suggest that T. sylvatica fruits has toxic activity rather than CNS depressant activity in mice and that this effect might be related to the presence of 28-O-[b-L-6-rhamnopyranosyl]-R 1 -barrigenol, one of the active principles of T. sylvatica fruits with sedative and toxic effect.

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Section: Effect On Motor Coordination On Rota-rod Testmentioning

confidence: 96%

“…Each mouse was observed for the loss of righting reflex (hypnosis) and duration of sleep. The time between loss and recovery of the righting reflex was recorded as sleeping time (González-Trujano et al, 1998).…”

Section: Sodium Pentobarbital-induced Hypnosismentioning

confidence: 98%

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice

Balderas-López

Alfaro-Romero

Monroy

et al. 2013

Pharmaceutical Biology

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“…A. diversifolia's root bark aqueous extract significantly delayed the onset of seizures induced by pilocarpine as it had reportedly produced GABA neurotransmission by blocking the chloride linked channels linked to GABAA-receptors [23]. It was observed that it may also be due to one or more of the known mechanisms of anticonvulsant action, such as alteration of Na+/k+ATPase expression and inhibition of expression of inducible nitric oxide.…”

Section: Annona Diversifoliamentioning

confidence: 99%

Anticonvulsant Properties of Some Medicinal Plants- A Review

Srinivasan¹,

Anitha²

2017

Asian J Pharm Clin Res

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Introduction: Epilepsy is the tendency to have seizures that start in the brain. The brain uses electrical signals to pass messages between brain cells and when these signals are disrupted, it leads to a seizure. A number of synthetic antiepileptic drugs are available in practice, but various medicinal plants act as an important source of treatment for epilepsy; plants such as Aeollanthus suaveolens, Passiflora caerulea, Persea americana, Annona diversifolia, and Boerhavia diffusa have good anticonvulsant activity.

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“…In contrast, diazepam, used as reference drug, produced an anxiolytic effect with a significant and dosedependent decrease in motor coordination accompanied by disruption of traction performance. Behavioral studies suggest an anti-anxiety effect produced by palmitone but its neuropharmacological profile differs from that observed for benzodiazepines such as diazepam (González-Trujano et al, 1998;.…”

Section: Annona Diversifolia Saff Annonaceaementioning

confidence: 99%

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

Gutierrez

Reyes-Chilpa

Jaime

2014

Revista Brasileira de Farmacognosia

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Some pharmacological effects of the ethanol extract of leaves ofAnnona diversifolia on the central nervous system in mice

Cited by 45 publications

References 2 publications

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice

Anticonvulsant Properties of Some Medicinal Plants- A Review

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

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Some pharmacological effects of the ethanol extract of leaves ofAnnona diversifolia on the central nervous system in mice

Cited by 45 publications

References 2 publications

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R1-barrigenol as a new compound with toxic effects in mice

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R1-barrigenol as a new compound with toxic effects in mice

Anticonvulsant Properties of Some Medicinal Plants- A Review

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

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Product

Resources

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Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice

Toxic rather than neuropharmacological effect ofTernstroemia sylvaticafruits and identification of 28-O-[β-l-6-rhamnopyranosyl]-R₁-barrigenol as a new compound with toxic effects in mice