Some Pharmacological and Chemotherapeutic Properties of Notatin

Abstract

This paper includes descriptions of work carried out by colleagues in other member firms of the Therapeutic Research Corporation; such work is referred to under the name of the worker responsible ; fuller reference to these colleagues is made in the acknowledgment at the end of the paper.

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery

“…Release of GOx-NG was likely prevented due to its much larger size (∼12 nm) than insulin, thereby reducing the potential local and systemic toxicity of GOx. 31 The in vivo performance of the core−shell MN array patches was evaluated in a mouse model of type 1 diabetes induced by streptozotocin (STZ). The mice were divided into six groups:…”

“…30 Moreover, the simultaneous release of GOх with insulin has the potential to cause systemic toxicity. 31 Moving forward, the next generation of smart insulin delivery should be developed to prioritize rapid responsiveness, ease of preparation and administration, and excellent biocompatibility.…”

Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation

“…For example, GOx catalyzes the oxidation of glucose to gluconic acid and H 2 O 2 , the latter of which can cause inflammation or even severe tissue damage . In addition, GOx may cause a host immune response; this is also a problem that has been encountered with Con A . The toxicity of PBA for human remains unclear; therefore, a thorough evaluation of its biosafety must be accomplished prior to translational studies in humans.…”

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade‐Triggered Insulin Delivery

“…However, the typical pH change‐triggered response of materials is often accompanied by slow changes in the conformation and morphology of materials and formulations under a physiological condition. [5e] In addition, the in vivo release of GOx from medical devices may cause potential toxicity, as well as the concerns over long‐term biocompatibility of the H 2 O 2 generated during oxidation of glucose . Therefore, the ongoing development of smart insulin delivery systems is focused on achieving several merits, including rapid responsiveness, ease of preparation and administration, as well as excellent biocompatibility…”