Some peculiar properties of cross-linked polyvinyl alcohol (CL-PVA) related to the reticulation degree

Mateescu, Mircea‐Alexandru; Schell, H.; Dimonie, M.; Todireanu, S.; Maior, O.

doi:10.1007/bf00265481

Cited by 21 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, physical cross-linking by successive freezing and thawing steps, as proposed by Mano et al [24] and by Mongia et al, [25] generates cryogels with a high propensity for swelling in water, which can be improper for use as a vascular implant. [26] Cross-linking of PVA can also be achieved by other physical procedures (UV or gamma radiation) or by using chemical cross-linkers such as glutaraldehyde, [27] formaldehyde [8] or epichlorohydrin [10] with some limitations particular to applications as implants. Furthermore, chemically cross-linked PVA presents a high crystallinity and consequently poor elasticity and resistance.…”

Section: Discussionmentioning

confidence: 99%

“…The good mechanical properties of cross-linked PVA materials can be explained by a stabilization of the polymeric network by hydrogen bonding. [10] The aim of this study was to design a simple process of PVA cross-linking with sodium trimetaphosphate (STMP), a largely accepted food cross-linker, [11] to form membrane devices for implantable vascular grafts. To our knowledge, although it is a major interest for implants based on PVA, there are no sodium trimetaphosphate cross-linked PVA vascular grafts implanted in vivo.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Cross‐linked Poly(vinyl alcohol) (PVA) for Vascular Grafts

Chaouat

Visage

Baille

et al. 2008

Adv Funct Materials

171

159

View full text Add to dashboard Cite

Poly(vinyl alcohol) (PVA) is a water‐soluble synthetic polymer with excellent film‐forming, emulsifying, and adhesive properties. The aim of this study is to design a simple process for PVA cross‐linking with sodium trimetaphosphate to form membrane devices suitable for biomedical applications. This procedure requires no organic solvent, nor melting process to obtain films with high mechanical strength. Fabrication of a small diameter tube from a PVA film is easy with a single wrapping step around a Teflon rod. Dynamic mechanical analysis demonstrated that, upon removal of the applied stress, the PVA film with a Young's modulus of 2 × 105 kPa returns to its original size and shape. The wall thickness of PVA tubes is 344 ± 13 µm (n = 12), which is close to the wall thickness of a human artery (350–710 µm). Suture retention of a PVA tube is excellent (140 ± 11 g), close to that of human vessels. The burst pressure of PVA tubes is found to be 507 ± 25 mm Hg, more than three times higher than the human healthy systolic arterial pressure. Under arterial pressure, there was no leakage even after needle puncture, contrary to clinical vascular expanded polytetrafluoroethylene prostheses. Finally, PVA tubes of 2 mm in diameter are used to replace a segment of an infrarenal aorta in rats. For at least one week, no mechanical nor thrombotic complications are noticed even in the absence of anticoagulant or antiplatelet treatment. Graft patency is also evidenced with non‐invasive imaging techniques. As a conclusion, this novel cross‐linking method confers to poly(vinyl alcohol) particular mechanical properties such as compliance, elasticity and resistance to mechanical stress, compatible with the circulatory blood flow.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Cross‐linked Poly(vinyl alcohol) (PVA) for Vascular Grafts

Chaouat

Visage

Baille

et al. 2008

Adv Funct Materials

171

159

View full text Add to dashboard Cite

show abstract

“…An example is the cross-linked dextran (Sephadex ® , a known chromatographic material type) (Hagel, 2001); at increasing cld, continuous decrease of swelling and of water regain were found. PVA was the first material for which we have noticed non-monotonous dependencies of these properties on the cld (Mateescu et al, 1984); high amylose starch was the second (Lenaerts et al, 1991;Mateescu et al, 1995). PVA was the first material for which we have noticed non-monotonous dependencies of these properties on the cld (Mateescu et al, 1984); high amylose starch was the second (Lenaerts et al, 1991;Mateescu et al, 1995).…”

Section: Hydrogen Association and Flexibility Of Chainsmentioning

confidence: 84%

The concept of self-assembling and the interactions involved

2015

Controlled Drug Delivery

View full text Add to dashboard Cite

“…The water holding capacity of the hydrogels is mainly due to the increase in cross-linking density. The amount of water present in a hydrogel may vary from 10 % to thousand times the initial weight of the polymer (Mateescu 1984). They are usually insoluble due to the presence of this covalent cross-link.…”

Section: Physical and Chemical Cross-linkingmentioning

confidence: 99%

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Rojas

2015

Excipient Applications in Formulation Design and Drug Delivery

View full text Add to dashboard Cite

There are many approaches to combine drug and polymers. One of them involves the use of drug-polymer conjugates in which the drug is covalently bounded to a polymer through a hydrolyzable linkage. However, the most widely used approach involves polymers as matrixes in which the drug and polymer are mixed physically and the release is achieved by diffusion from the surrounding polymeric matrix or by disintegration of the polymeric matrix. Nevertheless, most biopolymers per se do not possess adequate physicochemical and mechanical properties to produce a film or hydrogel which can be used as a matrix for the controlled release of drugs. For this reason, many cross-linking agents have been used to improve these polymer properties. The most reactive and typical cross-linking agent employed is glutaraldehyde. This chapter discusses the modification of drug release properties of polymers suchs as poly(vinyl) alcohol, chitosan, gelatin, alginates, carrageenan and naturally occurring gums by chemical modification via glutaraldehyde cross-linking. Most cross-linked products are more amorphous due to the reduction of the hydroxyl network responsible for cross-linking, crystallinity and water interaction.

show abstract

Some peculiar properties of cross-linked polyvinyl alcohol (CL-PVA) related to the reticulation degree

Cited by 21 publications

References 1 publication

A Novel Cross‐linked Poly(vinyl alcohol) (PVA) for Vascular Grafts

A Novel Cross‐linked Poly(vinyl alcohol) (PVA) for Vascular Grafts

The concept of self-assembling and the interactions involved

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Contact Info

Product

Resources

About