Some Patients With Cerebral Aneurysms Are Deficient in Type Iii Collagen

Pope, F M; Narcisi, P; Neil‐Dwyer, G.; Nicholls, A C; Bartlett, John R.; Doshi, B.S.

doi:10.1016/s0140-6736(81)91735-9

Cited by 135 publications

(25 citation statements)

References 12 publications

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“…While the direct causes of the defects themselves are unknown, they probably result from mechanical factors.There is no evidence available to suggest that such defects represent areas of decreased wall resistance that lead to the development of cerebral aneurysm. Studies have underscored the importance of the elastic, collagen and muscle elements in the pathophysiology of the cerebral arteries [5][6][7] . In the cerebral arteries the incidence of aneurysm is high.…”

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confidence: 99%

Histomorphometrical study of the elastic fiber system in the anterior cerebral artery of man

Chopard

Gerhard

2000

Arq. Neuro-Psiquiatr.

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-The aim of the present study was to quantify the distribution of the elastic fiber system within the wall of the anterior cerebral artery. The study is based on the works of Glynn (1940) and Stehbens (1989) concerning the incidence and origin of brain aneurysms and recent studies of the elastic fibers. The anterior cerebral artery was divided into three segments, S1, S2 and S3: S1 corresponds to the origin of the anterior cerebral artery, S2 is located at the junction of the anterior cerebral artery with the anterior communicating artery, and S3 at the junction of the rostrum and genu of the corpus callosum,which were submitted to routine histological procedures. A histomorphometrical study was undertaken using an estimation of the linear density (Ld) of the components of the fibrous elastic system which evaluates their full length in each segment. Data were analyzed using first order linear regression methods. The results show a decreasing quantity of elastic fibers in the three segments (S1>S2>S3). Study of the elastic fiber system may originate new concepts regarding the genesis of cerebral artery aneurysm.KEY WORDS: elastic fibers, cerebral arteries, anterior cerebral artery, aneurysm. Estudo histomorfométrico do sistema de fibras elásticas da artéria cerebral anterior no homem

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confidence: 99%

Histomorphometrical study of the elastic fiber system in the anterior cerebral artery of man

Chopard

Gerhard

2000

Arq. Neuro-Psiquiatr.

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“…3 Inherited abnormalities in type III collagen have been suggested as an important factor contributing to an altered vascular extensibility and weakening of the cerebral artery wall. 4 - 5 The widespread recognition and treatment of hypertension and improved neurosurgical management may have had an impact on the apparent decline in mortality from SAH, which has been reported in Sweden and elsewhere. 2 - 6 Atherosclerosis is a widespread disorder in Western societies that results from complex interactions between environmental and genetic risk factors.…”

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Are cerebral aneurysms atherosclerotic?

Adamson

Humphries

Østergaard

et al. 1994

Stroke

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Background and Purpose The aim of our study was to investigate plasma and genetic risk factors for rupture of cerebral aneurysms.Methods In London, a case-control study was made of 56 consecutive patients admitted to a regional neurosurgical service for treatment of ruptured cerebral aneurysm and of 93 control subjects. A further 40 consecutive patients admitted in Arhus with ruptured cerebral aneurysm also were studied.Results The British case-control study showed that smoking was associated with an increased risk of ruptured cerebral aneurysm (odds ratio, 9.1; 95% confidence interval [CI], 3.4 to 23.8; P<.001 for a history of >10 pack years). After age and sex adjustment, factors associated with ruptured cerebral aneurysm included a cholesterol concentration in the highest tertile (^6.3 mmol/L; odds ratio, 10.2; 95% CI, 3.9 to 26.7; P<.001), an apolipoprotein B concentration in the highest tertile (a0.84 g/L; odds ratio, 6.4; 95% CI, 2.5 to 16.3; / > <.001), and concentrations of HDL cholesterol in the lowest tertile (<1.1 mmol/L; odds ratio, 3.6; 95% CI, 1.4 to 8.2; P<.01). History of hypertension was of less importance (odds ratio, 4.0; 95% CI, 1.41 to 11.7; /><.01). Smoking history

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“…There is evidence that alterations in either the quantity (Gaetani et al, 1997;Ostergaard and Oxlund, 1987;van den Berg et al, 2001) or quality (Whittaker et al, 1988) of collagen may be related to the development of cerebral aneurysms. In some patients with congenital cerebral aneurysms, the etiology of the disease has been ascribed to an inherited type III collagen deficiency (Ehlers-Danlos syndrome), which causes arterial fragility (Pope et al, 1981). Moreover, a recent study has identified a significant association of familial intracranial aneurysm with a single nucleotide polymorphism (SNP) in the type I collagen gene (COL1A2), which results in an alanine to proline substitution at the amino acid 459 located on a triple-helical domain (Yoneyama et al, 2004).…”

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confidence: 99%

A novel arterial pouch model of saccular aneurysm by concomitant elastase and collagenase digestion

Yang

2007

J. Zhejiang Univ. - Sci. B

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Abstract:Background: An ideal aneurysm model of cerebral aneurysm is of great importance for studying the pathogenesis of the lesion and testing new techniques for diagnosis and treatment. Several models have been created in rabbits and are now widely used in experimental studies; however, every model has certain intrinsic limitations. Here we report the development of a novel saccular aneurysm model in rabbits using an arterial pouch that is subject to in vitro pre-digestion with combined elastase and collagenase. Methods: A segment of right common carotid artery (CCA) was dissected out and treated with elastase (60 U/ml, 20 min) followed by type I collagenase (1 mg/ml, 15 min) in vitro. The graft was anastomosed to an arterial arch built with the left CCA and the remaining right CCA, while the other end of the graft was ligated. The dimension and tissue structure of the pouch were analysed immediately, 2 or 8 weeks after operation. Findings: Ten terminal aneurysms were produced. The gross morphology of the aneurysm resembles the human cerebral terminal aneurysms. We have observed the following pathological changes: (1) growth of the aneurysm (mean diameter increased from (2.0±0.1) to (3.2±0.3) mm at 2 weeks, P<0.001, n=7~10); (2) thinning of the aneurysmal wall (the mean wall thickness decreased to 44% at 2 weeks), which was accompanied by significant losses of elastic fibres, collagen and the cellular component; and (3) spontaneous rupture (3 out of 9, one aneurysm ruptured 24 h after operation with the other two at 2 and 4 weeks respectively). Conclusion: This rabbit arterial pouch model mimics human cerebral aneurysms in relation to morphology and histology. In particular, this model exhibited an increased tendency of spontaneous rupture.

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Some Patients With Cerebral Aneurysms Are Deficient in Type Iii Collagen

Cited by 135 publications

References 12 publications

Histomorphometrical study of the elastic fiber system in the anterior cerebral artery of man

Histomorphometrical study of the elastic fiber system in the anterior cerebral artery of man

Are cerebral aneurysms atherosclerotic?

A novel arterial pouch model of saccular aneurysm by concomitant elastase and collagenase digestion

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