Some observations on the penetration of antimicrobial drugs into the respiration secretions of horses

Dixon, PA; Thomson, Jill R.; Brown, R. G.; Galbraith, Alan; Bogan, J. A.

doi:10.21836/pem19850708

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“…However, its inability to penetrate effectively into purulent exudate is well documented. 35,39,40 The presence of facultatively anaerobic Gramnegative bacteria in 85% of cases would suggest the use of an additional agent ( Table 4). Many of the isolates in this study were susceptible to gentamicin in vitro although gentamicin is also said to lack good penetration into respiratory tract secretions.…”

Section: Discussionmentioning

confidence: 99%

“…This was not surprising, since both bacterial and tissue factors influence the results of antimicrobial therapy. 39,40,[42][43][44][45] The lesions in cases that were necropsied were often extremely severe and the association between delayed onset of treatment (as little as 24 h) and failure to recover from infection involved in significant disease which may not be reversible if treatment is not prompt and aggressive.…”

Section: Discussionmentioning

confidence: 99%

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Bacterial infection of the lower respiratory tract in 34 horses

Racklyeft¹,

Love

2000

Aust Veterinary J

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There was no association between the isolation of any specific bacterium and the outcome of disease. However, obligately anaerobic bacteria (such as anaerobic cocci, Bacteroides tectum, P heparinolytica and Fusobacterium spp) and the facultatively anaerobic species Escherichia coli, were recovered more commonly from horses that died or were euthanased than from those that survived. There was an association between failure of horses to recover from pleuropneumonia and delay in diagnosis and initiation of treatment.

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Section: Discussionmentioning

confidence: 99%