Some observations on the lactate dehydrogenase of human neoplasic tissue

Starkweather, William H.; Schoch, Henry K.

doi:10.1016/0006-3002(62)90281-0

Cited by 53 publications

(11 citation statements)

References 3 publications

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“…It is released into the peripheral blood after cell death by, eg: ischemia, excess heat or cold, starvation, dehydration, injury, exposure to bacterial toxins, after ingestion of certain drugs, and from chemical poisonings. A relationship between neoplasia and increased LDH levels has been reported in both human and animal tumors [24]. Increased activity of LDH in serum can be used as an indicator of cellular damage and cytotoxicity of pesticides [25].…”

Section: Discussionmentioning

confidence: 99%

Oxycarotenoid Lutein Reverses the Toxicity Induced by Carbofuran in Wistar Rats

Purushothaman

Valsan

Kuttan

2018

Int J Pharm Pharm Sci

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Objective: Elucidation of the protective effect of lutein against carbofuran induced toxicity in Wistar rats. Methods:Male Wistar rats were assigned into 5 groups of five animals. Group I normal received sunflower oil, Group 2 received carbofuran (5 mg/kg b. w.) alone. Group 3-5 received carbofuran plus lutein (50, 100 and 200 mg/kg body weight) respectively. Carbofuran and lutein administration were continued for 14 d. Neurobehavioural markers such as rotarod, grip strength test and pain threshold tests were carried out. After sacrifice, tissues were analysed for marker enzymes, antioxidant enzymes as well as oxidative stress markers.Results: Low dose of carbofuran was found to produce neurobehavioral problems as seen from the decreased retention time during rotarod test, endurance capacity in grip strength test and increased endurance capacity in pain threshold test. They were found to be significantly reversed by oral lutein administration. Administration of lutein restored the decreased acetylcholinesterase produced by carbofuran. Serum and tissue marker enzymes such as lactate dehydrogenase, creatine kinase and gamma-glutamyltransferase, which were increased by carbofuran were decreased by lutein administration. Lutein administration also reduced oxidative stress parameters which were increased by carbofuran. Conclusion:The results showed that carbofuran induced toxicity in male Wistar rats was reversed by carotenoid lutein.

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Section: Discussionmentioning

confidence: 99%

Oxycarotenoid Lutein Reverses the Toxicity Induced by Carbofuran in Wistar Rats

Purushothaman

Valsan

Kuttan

2018

Int J Pharm Pharm Sci

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“…Nonetheless the total LDH activity in both fresh granulosa cells and the cell line were closely identical (data not shown). An increase in LDH-M is a common feature in the majority of cancers and transformed cell lines [7,8], Cooper et al [9] have shown that the LDH isoenzymes are phosphorylated by tyrosine in the cells transformed by viruses whose transforming proteins are tyrosine protein kinases. These oncogenic transfor mation-related changes also suggest an im portant role of this enzyme in tumorigenesis or cell transformation.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Lactate Dehydrogenase Isoenzymes and Phosphofructokinase Activity in the Hormonally Induced G-XII Cell Line

Malik¹,

Sharma²,

Chandiok³

et al. 1988

Pathobiology

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G-XIIcell line was earlier developed in our laboratory from the granulosa lutein cells of goat ovaries, subjected to sustained stimulation by ovine luteinizing hormone. It is a non-clonogenic and non-tumorigenic cell line which secretes progesterone. In the present paper, we report some biochemical findings on the cell line studied between passages 10 and 15. The cells exhibited a shift in the lactate dehydrogenase isoenzyme pattern from the heart form to muscle form and a 300 % increase in the phosphofructokinase activity compared to fresh granulosa cells.

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“…The isozymic pattern of lactic-dehydrogenase in cancer was first studied by Richterich et al [21] and Starkweather and Schoch [32].…”

Section: Ill Discussionmentioning

confidence: 99%

Fetal-like Patterns of Lactic-Dehydrogenase and Aldolase Isozymes in some Pathological Conditions

Schapira¹,

Dreyfus²,

Schapira³

1966

Enzymol Biol Clin

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A study of the variations of multiple molecular forms of two enzymes, lactic dehydrogenase and aldolase, has been conducted in muscular diseases and in cancer. The changes in LDH patterns are most characteristic in muscle diseases. The trend is toward the reappearance of a fetal-like pattern. Aldolase shows a modification of specificity in cancerous tissues and in atrophied muscle. The most interesting change is the regression of the liver-specific aldolase in human and experimental hepatomas.

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Some observations on the lactate dehydrogenase of human neoplasic tissue

Cited by 53 publications

References 3 publications

Oxycarotenoid Lutein Reverses the Toxicity Induced by Carbofuran in Wistar Rats

Oxycarotenoid Lutein Reverses the Toxicity Induced by Carbofuran in Wistar Rats

Alterations in Lactate Dehydrogenase Isoenzymes and Phosphofructokinase Activity in the Hormonally Induced G-XII Cell Line

Fetal-like Patterns of Lactic-Dehydrogenase and Aldolase Isozymes in some Pathological Conditions

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