Some observations on an induced adaptation in a transplantable tumor

Establishment of transplantable porcine tumor cell lines derived from MHC- inbred miniature swine

“…[50][51][52] Based on literature in murine systems, such changes in surface markers may be overcome by immediate direct, serial transfer of tumor cells between animals, while genetic differences may be circumvented using conditions favoring tumor growth, such as the dose of cells given to the host animal or the environment into which the cells are injected. 40,47,48,[53][54][55][56][57] Overall, our results indicate the feasibility of a large-animal transplantable tumor model using cells derived from spontaneous …”

“…Although this risk is minimized by matching of major and many minor histocompatibility loci, there may be other minor or unknown antigens present that can still be recognized as foreign by the host immune system. [46][47][48][49] Conversely, a lack of antigens or surface markers may also contribute, as markers necessary for in vivo growth of our porcine tumor lines may be lost by in vitro culturing. With some murine tumors, the loss of surface sialoglycoproteins abolished the ability to transplant tumor cell lines that could previously be transferred within and across strains.…”