Some observations of the bronchial arteries in lobar pneumonia and pulmonary infarction

Cudkowicz, Leon

doi:10.1016/s0366-0869(52)80005-x

Cited by 16 publications

(13 citation statements)

References 5 publications

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“…The bronchial artery circulation in acute pneumonia is generally considered to be increased (LIEBOW et coli, 1959). However, in 3 cases of lobar pneumonia in man, the bronchial arteries post mortem were found to be blocked in the earlier phases of the pneumonia (CUDKOWICZ 1951). In the present experimental lobar pneumonia marked parallel reduction in both pulmonary artery and bronchial artery flow was found and there was no evidence for bronchopulmonary shunts.…”

Section: Discussioncontrasting

confidence: 52%

Blood Flow in Pulmonary and Bronchial Arteries in Acute Experimental Pneumonia and Pulmonary Embolism

Björk¹,

McNeil²

1977

Acta Radiologica. Diagnosis

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Acute lobar pneumonia and pulmonary embolism were induced in rabbits and the blood flow in the pulmonary artery and bronchial arteries was determined using isotopic microspheres. In acute pneumonia the pulmonary artery flow to the involved lung was reduced 8.5 times and the bronchial artery flow was reduced 5.0 times compared to flow in the normal lung. In acute pulmonary embolism, both the pulmonary artery flow (2.3 times) and the bronchial artery flow (2.5 times) were also reduced. For all animals, the reduction in pulmonary artery flow paralleled the reduction in bronchial artery flow (r=0.65).

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Section: Discussioncontrasting

confidence: 52%

Blood Flow in Pulmonary and Bronchial Arteries in Acute Experimental Pneumonia and Pulmonary Embolism

Björk¹,

McNeil²

1977

Acta Radiologica. Diagnosis

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“…These changes were later confirmed and anatomical features elaborated upon by several investigators [15,27]. The usual features in the tuberculous lungs are distortion, tortuosity, and extensive ramification and proliferation of the bronchial arteries supplying the caseating areas.…”

Section: Chronic Lung Infectionsmentioning

confidence: 59%

“…The pulmonary arteries supplying the wall of the abscess are usually obliterated by infected thrombi, so that most of the blood supply to the walls of the abscess cavity comes from the bronchial circulation [27]. In addition to the growth of new vessels surrounding the diseased area, there is dilation of the smaller branches of the bronchial artery [15].…”

Section: Chronic Lung Infectionsmentioning

confidence: 99%

Bronchial vascular congestion and angiogenesis

Charan

Baile²,

Paré³

1997

Eur Respir J

104

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The bronchial vasculature is the systemic arterial blood supply to the lung. Although small relative to the pulmonary blood flow, the bronchial vasculature serves important functions and is modified in a variety of pulmonary and airway diseases.Congestion of the bronchial vasculature may narrow the airway lumen in inflammatory airway diseases, and formation of new bronchial vessels (angiogenesis) is implicated in the pathology of a variety of chronic inflammatory, infectious and ischaemic pulmonary diseases. The remarkable ability of the bronchial vasculature to remodel has implications for disease pathogenesis.The contributions of the bronchial vasculature to the pathogenesis of pulmonary disease are reviewed in this article. Eur Respir J 1997; 10: 1173-1180. The bronchial circulation is ideally situated to play an important role in lung defence and in the pathogenesis of a number of airway diseases. The bronchial microvasculature provides nutrient blood flow to the airway epithelium and is important for proper functioning of the mucociliary escalator. Bronchial blood flow is responsive to changes in neural and humoral stimuli and plays a role in conditioning of inspired air. The focus of this review is the potential involvement of the bronchial vasculature in contributing to the pathogenesis of a variety of airway diseases. In particular, we have focused on the possibility of airway narrowing as a consequence of bronchial vascular congestion, and the remarkable proliferative capacity of the bronchial vessels in response to a variety of pulmonary diseases. Bronchial vascular congestionHyperaemia of the bronchial vasculature is often included in descriptions of the pathology of asthma. An example of hyperaemia of the bronchial vasculature is shown in figure 1. This photomicrograph shows a crosssection of a human airway from a patient who died of asthma. The apparent increase in the size and number of vessels inside and outside the smooth muscle layer is clearly visible, suggesting that vascular dilation and proliferation (angiogenesis) could be important components of the airway wall remodelling in asthmatic patients. The airway vasculature is of considerable interest in asthma because it can contribute to the excessive airway narrowing, which is characteristic of this disease. A diagram of an airway ( fig. 2) illustrates the two bronchial vascular plexuses: the peribronchial plexus, located in the adventitial space between the muscle and the surrounding lung parenchyma; and the submucosal vascular plexus, located beneath the epithelial layer. Dilation, exudation or transudation from these vessels could contribute to the excessive airway narrowing observed in asthma. Relaxation of the bronchial vascular smooth muscle and/or an increase in the intravascular pressure will lead to congestion of these vessels. This bronchial vascular congestion could result in a reduction in the area of the airway lumen and/or an increase in the outer diameter of the airway. The latter effect could uncouple the airway smoo...

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“…In fact, Leonardo da Vinci was the first to describe new bronchial vessels forming a dense plexus around an inflammatory cavitary lesion in a human lung (15). Since this very early description, many different authors have reported on hypertrophy and angiogenesis of the bronchial circulation in response to different stimuli, including infections, occlusion of a pulmonary artery, tumors, and lung transplantation (16)(17)(18)(19)(20). In lung abscesses as well as in pulmonary tuberculosis, the pulmonary vessels adjacent to the lesion are obliterated by infected thrombi and the blood supply develops from the bronchial system (16).…”

Section: Discussionmentioning

confidence: 99%

“…In lung abscesses as well as in pulmonary tuberculosis, the pulmonary vessels adjacent to the lesion are obliterated by infected thrombi and the blood supply develops from the bronchial system (16). In an experiment that consisted of complete ligation of the left pulmonary artery, Liebow et al (18) observed an impressive expansion of the bronchial circulation associated with anastomoses between the bronchial and pulmonary systems. The functional importance of these changes is not clear.…”

Section: Discussionmentioning

confidence: 99%

A Novel Model for Post-Transplant Obliterative Airway Disease Reveals Angiogenesis from the Pulmonary Circulation

Dutly

Andrade

Verkaik

et al. 2005

American Journal of Transplantation

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We present a novel animal model for post-transplant obliterative airway disease in which the donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is technically more challenging than the heterotopic model of implantation into a subcutaneous pouch, it has several important advantages some of which are the appropriate local environment and the possibility of local immunosuppressive therapy after transtracheal gene, cell or drug delivery. This model has revealed new insights into angiogenic potential of the pulmonary circulation.

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Some observations of the bronchial arteries in lobar pneumonia and pulmonary infarction

Cited by 16 publications

References 5 publications

Blood Flow in Pulmonary and Bronchial Arteries in Acute Experimental Pneumonia and Pulmonary Embolism

Blood Flow in Pulmonary and Bronchial Arteries in Acute Experimental Pneumonia and Pulmonary Embolism

Bronchial vascular congestion and angiogenesis

A Novel Model for Post-Transplant Obliterative Airway Disease Reveals Angiogenesis from the Pulmonary Circulation

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