Some Observations Concerning ¹H‐NMR. Spectra of 5‐hydroxy‐ and 5‐acetoxy‐steroid compounds

Abstract

It was found that analysis of the 1H‐NMR. signals (at 360 (preferably) and/or 100 MHz) of the protons at C (4) and of the equatorial α‐proton at C (6), particularly when these are located in the 2–3 ppm region and therefore convenient for detection and identification, may be of valuable aid in the structural and configurational characterization of 5‐hydroxy‐ and 5‐acetoxy‐steroids (unsubstituted or containing a hydroxy or acyloxy substituent at C (3)).