Some Non‐<scp>FDA</scp> Approved Uses for Neuromodulation: A Review of the Evidence

Lee, Samuel; Abd‐Elsayed, Alaa

doi:10.1111/papr.12405

Cited by 11 publications

(8 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditional spinal cord stimulation (SCS) is a minimally invasive, fully reversible treatment for postsurgical chronic back and leg pain (failed back surgery syndrome [FBSS]) , chronic peripheral neuropathic pain , complex regional pain syndrome and, less frequently, chronic peripheral vascular disease, and refractory angina . SCS uses implanted epidural electrodes to stimulate the spinal dorsal columns, delivering electrical pulses at frequencies of approximately 40–70 Hz.…”

Section: Introductionmentioning

confidence: 99%

Prospective, Randomized, Sham-Control, Double Blind, Crossover Trial of Subthreshold Spinal Cord Stimulation at Various Kilohertz Frequencies in Subjects Suffering From Failed Back Surgery Syndrome (SCS Frequency Study)

Al‐Kaisy

Palmisani

Pang

et al. 2018

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Prospective, Randomized, Sham-Control, Double Blind, Crossover Trial of Subthreshold Spinal Cord Stimulation at Various Kilohertz Frequencies in Subjects Suffering From Failed Back Surgery Syndrome (SCS Frequency Study)

Al‐Kaisy

Palmisani

Pang

et al. 2018

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

“…Other uses, including phantom limb pain and chronic refractory angina, are less common but have growing evidence (table 1). 27 28 In contrast to traditional SCS, DRGS revolves around modulating focal pain-conducting neurons in a specific dermatomal distribution29 and is commonly used for focal pain syndromes and CPRS (table 1). 30 Irrespective of the type of device, electrical currents are delivered at either low (10–200 Hz) or high (500 Hz–10 kHz) frequencies to alter pain perception 31.…”

Section: Neuraxial Devicesmentioning

confidence: 99%

Perioperative and anesthetic considerations for the management of neuromodulation systems

Orhurhu

Hussain

Karri

et al. 2023

Reg Anesth Pain Med

Self Cite

View full text Add to dashboard Cite

The use of neuromodulation systems is increasing for the treatment of various pathologies ranging from movement disorders to urinary incontinence to chronic pain syndromes. While the type of neuromodulation devices varies, they are largely categorized as intracranial (eg, deep brain stimulation), neuraxial (eg, spinal cord stimulation, dorsal root ganglion stimulation, and intrathecal drug delivery systems), or peripheral (eg, sacral nerve stimulation and peripheral nerve stimulation) systems. Given the increasing prevalence of these systems in the overall population, it is important for anesthesiologists, surgeons, and the perioperative healthcare team to familiarize themselves with these systems and their unique perioperative considerations. In this review, we explore and highlight the various neuromodulation systems, their general perioperative considerations, and notable special circumstances for perioperative management.

show abstract

“…Other less common indications include phantom limb pain and chronic refractory angina. 18 Spinal cord stimulators consist of single or multiple leads containing electrodes that are placed between the spinal cord and the vertebrae in the epidural space. Although early SCS systems utilized electrodes that were inserted surgically via mini laminectomy or laminotomy, less invasive percutaneous placed electrodes have become utilized more frequently 17 The placement of the leads in the epidural space varies depending on the condition being treated and the electrodes can be placed at any level from the cervical to sacral regions.…”

Section: General Overview Of Neurostimulatorsmentioning

confidence: 99%

Anesthesia management in patients with neurostimulators

Rathore

Dinsmore

Venkatraghavan

2023

International Anesthesiology Clinics

View full text Add to dashboard Cite

Neurostimulators are active implantable devices that clinicians use to perform diverse neuromodulation treatments in patients with neurological and non-neurological disorders. 1 Neuromodulation works on the principle of reverse engineering the disorder allowing the clinicians to think from a patient-system point of view. This enables them to personalize interventions by understanding the patient-specific pathophysiology that can translate insights from cognitive neuroscience into targeted therapies for various disorders. 2 Neurostimulators can be intracranial [deep brain stimulation (DBS)], neuraxial [spinal cord stimulation (SCS), sacral nerve stimulators], or peripheral (vagal nerve trigeminal nerve or other peripheral nerve stimulation). The number of patients using neurostimulators is growing rapidly, making it imperative for anesthesiologists to understand these devices and their potential interactions with other medical equipment. 3 The literature on perioperative management of patients with neurostimulators is scarce, and most of the information comes from case reports and manufacturer recommendations. In this review, we provide an overview of various neurostimulators, general considerations, and recommendations regarding the perioperative management of these patients for specific surgeries.

show abstract

Some Non‐FDA Approved Uses for Neuromodulation: A Review of the Evidence

Abstract: This review article shows compelling evidence based on clinical trials that neuromodulation can be of benefit for patients with serious painful conditions that are not currently approved by the FDA.

Cited by 11 publications

References 62 publications

Prospective, Randomized, Sham-Control, Double Blind, Crossover Trial of Subthreshold Spinal Cord Stimulation at Various Kilohertz Frequencies in Subjects Suffering From Failed Back Surgery Syndrome (SCS Frequency Study)

Prospective, Randomized, Sham-Control, Double Blind, Crossover Trial of Subthreshold Spinal Cord Stimulation at Various Kilohertz Frequencies in Subjects Suffering From Failed Back Surgery Syndrome (SCS Frequency Study)

Perioperative and anesthetic considerations for the management of neuromodulation systems

Anesthesia management in patients with neurostimulators

Contact Info

Product

Resources

About