Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

Abstract

Ethnopharmacological significance Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. Aim of the study To carry out a collaborative preliminary modern scientific evaluation of the efficacy of some Nigerian ethnomedicines used by traditional medicine practitioners (TMPs) in the management of tuberculosis and related ailments Materials and methods Ethnomedicinal recipes (ETMs) were collected from TMPs from locations in various ecological zones of Nigeria under a collaborative understanding. The aqueous methanolic extracts of the ETMs were screened against Mycobacterium bovis, BCG and Mycobacterium tuberculosis (M. tb.) strain H37Rv using the broth microdilution method. Results Extracts of ETMs screened against BCG showed 69% activity against the organism. The activities varied from weak, ≤ 2500μg /mL to highly active, 33μg /mL 64% of the extracts were active against M. tb. The activities of the extracts against M.tb. varied from weak, ≤ 2500μg /mL to highly active, 128μg/mL. There was 77% agreement in results obtained using BCG or M. tb. as test organisms Conclusion The results show clear evidence for the efficacy of the majority of indigenous Nigerian herbal recipes in the ethnomedicinal management of tuberculosis and related ailments. BCG may be effectively used, to a great extent, as the organism for screening for potential anti-M. tb. agents. A set of prioritization criteria for the selection of plants for initial further studies for the purpose of antituberculsis drug discovery research is proposed.

Comparative in vitro cytotoxic, anti-inflammatory and anti-microbiological activities of two indigenous Venda medicinal plants

“…Due to increase in multi drug resistance (MDR) and extensively drug resistance TB (XDR) strains of M. tuberculosis, the need of discovering newer anti-mycobacterial agents to eradicate the infections has increased. A study by Ibekwe et al, [15] showed that Pterocarpus osun Craib exhibited an MIC value of 1225 μg/ml against strain H37.…”

Ethnobotanical Survey of Plants Used for Treating Cough Associated with Respiratory Conditions in Ede South Local Government Area of Osun State, Nigeria

“…For instance, the use of Psidium guajava for the treatment of cough has been documented in Pakistan [63], Uganda [64,65], South Africa [27], and Zimbabwe [66]. On the other hand, Garcina kola has been extensively documented as a cough remedy in Nigeria [29,36,49] but no record has been found in other parts of the world. Furthermore, reports of the use of approximately 32% of the plants such as Corchorus olitorius, Hybanthus enneaspermus and Theobroma cacao as cough remedy in folk medicine were not found ( Table 2).…”

Phytochemical Compositions in Some Nigerian Medicinal Plants and Their Pharmacological Properties: A Review

“…Awomukwu et al, [81] investigated the presence of alkaloids, flavonoids, saponins, tannins and little amount of phenols on stem, pod and root extract of C. sieberiana and reported the antiulcer, antidiarrhoeal, antimalarial, antitrypanosomal and other pharmacological activities. Reference [82] reported the antimycobacterium activity of C. sieberiana.…”