Some New Tuberculostatic Thiosemicarbazones

Antitubercular Substances. I. Alkyl, Aralkyl, Aryl, and Cyclic Hydrazides and Miscellaneous Nitrogenous Derivatives*

“…as noted in the tables, have also recently been reported by Bernstein, et al (2), by Buu-Hoi, et al (3)(4)(5)(6), and by Gardner, et al (7).…”

“…This compound may have been investigated by Buu-Hoi, el at. (6); they named it (1-naphthy1)acetic hydrazide but gave the structural formula for 1-naphthoic hydrazide. Their compound was inhibitory a t a concentration of 10-5 against the BCG strain of Mycobacferium tuberculosis by their method of evaluation; isonicotinic hydrazide was inhibitory at a concentration of 10-a.…”

Thiosemicarbazones derived from indanedione-1, 3

“…NTIVIRAL (1-7) and tuberculostatic (8)(9)(10)(11)(12)(13)(14) ac-A tivity has been reported for thiosemicarbazones of different carbonyl compounds. Further work on the thiosemicarbazones led to the discovery of the antiviral activity of isatin-3-thiosemicarbazone (I) against the pox group of viruses in human and type 2 polio in ERK cells (15).…”

Antitubercular Substances. III. Nonpyridinoid Heterocyclic Hýdrazides*

“…The effect has been duplicated in vitro by the addition of large, highly asymmetrical molecules such as acacia (7) and pneumococcus polysaccharide (8). In vivo experiments have demonstrated the rate to be reduced by the salicylates (2, 4, [9][10][11]. This observation is of clinical significance as the salicylates are commonly self-administered and would thus interfere with the value of the sedimentation rate as a diagnostic aid.…”