Some new aspects of metabotropic glutamate receptors

Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes

“…Glutamate release or increased activity of EAATs in astrocytes could thus be a relevant mechanism of treatment in diseases involving glutamate-mediated cytotoxicity. On the other hand, glutamate can also promote oligodendrocyte differentiation by activating various glutamate receptors ( Tsitsilashvili et al, 2018 ), and it can also regulate the remyelination process ( Wheeler and Fuss, 2016 ). Thus, variation in astrocyte-dependent release and removal of extracellular glutamate may be essential in oligodendrocyte homeostasis.…”