Some New 2-Amino-4-(N-substituted-1H- indol - 3-yl) thiophene-3-carbonitriles and their Antimicrobial Properties
Abstract:NOVEL series of 2-amino-4-(N-substituted-1H-indol-3-yl) thiophene-3-carbonitriles (3a-f) were prepared via reaction of 2-(1-(N-substituted-1H-indol-3-yl) ethylidene) malononitriles (2a-f) with sulfur (Gewald reaction). Reaction of 3a-f with formic acid, formamide or malononitrile led to the formation of fused thieno [2,3d] pyrimidin-4(3H)-ones (6a-f) thieno[2,3-d] pyrimidin-4-amines (7a-f) and thieno[2,3-d] pyridine-3-carbonitriles (8a-f), respectively. On the other hand, a series of 2-(2-(4-nitrophenyl)-4-oxo… Show more
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