Some Monoaminergic Mechanisms Controlling Sleep and Waking

Jouvet, Michel

doi:10.1007/978-3-642-95201-2_10

Cited by 25 publications

(2 citation statements)

References 41 publications

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“…Self-stimulation was not obtained in NE cell concentrations caudal to the principal locus coeruleus, possibly corresponding to Group A4 of Dahlstrb'm and Fuxe (1965). This negative result, however, may be confounded by motor inhibitory effects that have been associated with this region (Jouvet, 1972).…”

Section: Discussionmentioning

confidence: 99%

Self-stimulation of noradrenergic cell group (A6) in locus coeruleus of rats.

Ritter¹,

Stein²

1973

Journal of Comparative and Physiological Psychology

141

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Twenty out of 21 electrodes in the almost exclusively noradrenergio cell concentrations of the locus coeruleus supported high and stable rates of selfstimulation. Locus coeruleus self-stimulation was facilitated by amphetamine and suppressed by chlorpromazine and a-methyl-p-tyrosine, but pimozide at relatively high dosea had almost no effect. These results demonstrate that self-stimulation can be localized in a relatively homogeneous noradrenergic site and thus provide presumptive evidence that at least some noradrenergic neurons specifically mediate rewarding effects.1 This report is based on portions of a dissertation submitted by the first author in partial fulfillment of the requirements for the PhD degree at Bryn Mawr College, 1973. Portions of this work were reported by Ritter and Stein (1972).a Requests for reprints should be sent to Sue

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Section: Discussionmentioning

confidence: 99%

Self-stimulation of noradrenergic cell group (A6) in locus coeruleus of rats.

Ritter¹,

Stein²

1973

Journal of Comparative and Physiological Psychology

141

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“…Finally, the activity of the LC NE-containing neurons have been related to wakefulness and paradoxical sleep (PS) by deficits resulting from electrolytic lesions and catecholamine depleting drugs (cf. Jouvet, 1972).…”

Section: Introductionmentioning

confidence: 99%

Activity patterns of catecholamine‐containing pontine neurons in the dorso‐lateral tegmentum of unrestrained cats

1974

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Single catecholamine-containing neurons in the dorso-lateral pontine tegmentum were recorded in unanesthetized, freely behaving cats. Microscopic lesions were made on each recorded unit and subsequently identified for catecholamines by fluorescence histochemical analysis. The majority of the NE-containing neurons exhibited low spontaneous discharge rates in quiet wakefulness and in slow wave sleep. I n paradoxical sleep, the medially located NE-containing neurons tend to exhibit bursting discharges which are closely related to individual PGO waves. The laterally or dorsally situated NE units fire more slowly and tend to decrease their firing activity during paradoxical sleep. Tonically active, relatively fast NE-containing units were also found. Often, those neurons showed greatly increased activity before the cat awoke from either slow wave sleep or paradoxical sleep, with activity persisting during the early moments of waking. The combination of histochemical and electrophysiologic methods proved essential for correlating neurochemistry and function within the heterogeneous NE-containing nuclei of the cat pons.

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Introduction:History and Scope of This Book

Exploring the Vertebrate Central Cholinergic Nervous System

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Some Monoaminergic Mechanisms Controlling Sleep and Waking

Cited by 25 publications

References 41 publications

Self-stimulation of noradrenergic cell group (A6) in locus coeruleus of rats.

Self-stimulation of noradrenergic cell group (A6) in locus coeruleus of rats.

Activity patterns of catecholamine‐containing pontine neurons in the dorso‐lateral tegmentum of unrestrained cats

Introduction:History and Scope of This Book

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