1988
DOI: 10.1073/pnas.85.24.9674
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Some mismatch repair activities in Escherichia coli.

Abstract: Heterozygous bacteriophage A DNA molecules, whose replication requires mismatch correction of a mutant nucleotide in the transcribed strand, provide an assay for localized mismatch repair in Escherichia coli. We describe two systems: one removes the A in C-A or G-A mismatches and the other removes one or the other C in a C C mismatch. Mutations disabling the first system result in a mutator phenotype that may be identical to mutY. Investigation of the products present in infective centers of bacteria transfect… Show more

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Cited by 124 publications
(114 citation statements)
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References 26 publications
(15 reference statements)
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“…An E. coli DNA mismatch glycosylase (MutY) that removes adenine from A\G mismatches was originally identified as a gene that prevented C : G A : T transversion mutations [93,94]. The mutator locus was designated mutY, and the repair activity was found to be independent of the methylation state of the DNA [94,95].…”
Section: G/t(u)-mismatch Dna Glycosylasesmentioning
confidence: 99%
See 1 more Smart Citation
“…An E. coli DNA mismatch glycosylase (MutY) that removes adenine from A\G mismatches was originally identified as a gene that prevented C : G A : T transversion mutations [93,94]. The mutator locus was designated mutY, and the repair activity was found to be independent of the methylation state of the DNA [94,95].…”
Section: G/t(u)-mismatch Dna Glycosylasesmentioning
confidence: 99%
“…The mutator locus was designated mutY, and the repair activity was found to be independent of the methylation state of the DNA [94,95]. mutY encodes a DNA glycosylase of 36 kDa which, in addition to excision of A opposite G and C, also removes A opposite the oxidized purines 8-oxoG and 7,8-dihydro-8-oxoadenine (8-oxoA) [96].…”
Section: G/t(u)-mismatch Dna Glycosylasesmentioning
confidence: 99%
“…MutY, structurally similar to Endo III [18][19][20][21], is another BER glycosylase that contains a [4Fe-4S] cluster [20]. However, MutY instead removes adenine from 8-oxo-guanine:adenine mispairs [22][23][24][25][26][27][28][29][30][31][32][33][34].…”
Section: Introductionmentioning
confidence: 99%
“…The presence of 8-OxoG in DNA has been shown to be mutagenic since, while this lesion does not impede DNA chain elongation, it preferentially pairs with adenine during in vitro DNA synthesis (Shibutani et al, 1991). The biological incidence of the presence of 8-OxoG in DNA has been unveiled by the study of two genes in E. coli, fpg (mutM) and mutY (micA) which code for DNA glycosylases that cooperate to prevent the mutagenic e ects of 8-OxoG in DNA (Boiteux et al, 1987;Cabrera et al, 1988;Radicella et al, 1988;Nghiem et al, 1988;Au et al, 1989). Inactivation of either gene leads to a spontaneous mutator phenotype characterized by the exclusive increase in GC to TA transversions (Michaels and Miller, 1992;Grollman and Moriya, 1993;Boiteux and Laval, 1997).…”
mentioning
confidence: 99%