Some medicinal properties of Cussonia and Schefflera species used in traditional medicine

Tetyana, P.; Prozesky, Erwin Antoni; Jäger, Anna K.; Meyer, J.J.M.; Staden, J. Van; Wyk, B.‐E. Van

doi:10.1016/s0254-6299(16)30454-9

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…Biological activities of C. spicata extracts and compounds isolated from the species include acetylcholinesterase [100], antibacterial [57,58,77,101,102], antiviral [101,103], anti-inflammatory [57,58], antileishmanial [104], antiplasmodial [57,58,63,64,102,[105][106][107], antiprotozoan [102], antioxidant [100], larvicidal [108,109], molluscicidal [60,110,111], spermicidal [112], and cytotoxicity [63,64,[102][103][104] activities.…”

Section: Biological Activities Of Cussonia Spicatamentioning

confidence: 99%

“…Tetyana [57] and Tetyana et al [58] evaluated anti-inflammatory activities of bark, leaves, roots, and stems ethanolic, ethyl acetate and water extracts of C. spicata using the cyclooxygenase (COX-1) assay. The Tannins -Root bark [28] Total flavonoids (mg catechin equivalents/g dry weight)…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

“…McGaw et al [114] evaluated toxicity activities of aqueous, methanol, and hexane root extracts of C. spicata using the brine shrimp lethality mortality assay against the larvae of Artemia salina with podophyllotoxin as a positive control. The only aqueous extract showed activities with median lethal concentration (LC 50 ) value of 2.6 μg/mL which was extracts inhibited cyclooxygenase in the cyclooxygenase-1 assay, with 56.0% being the highest inhibition [57,58].…”

Section: Toxicity Activitiesmentioning

confidence: 99%

Section: Antiplasmodial Activitiesmentioning

confidence: 99%

“…Tetyana [57] and Tetyana et al [58] evaluated antiplasmodial activities of bark ethanolic, ethyl acetate, and water extracts of C. spicata against Plasmodium falciparum in an in vitro assay, a slightly modified version of the parasite lactate dehydrogenase assay with chloroquine as a positive control. Weak inhibitory activities of 20% and 35% against water and ethanol extracts, respectively, at a concentration of 200 mg/ml were observed [57,58]. Kraft et al [105] Clarkson et al [106] evaluated antiplasmodial activities of C. spicata aqueous, dichloromethane, dichloromethane-methanol (1:1) fruit, and leaf extracts against Plasmodium falciparum using the parasite lactate dehydrogenase assay.…”

Section: Antiplasmodial Activitiesmentioning

confidence: 99%

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Cussonia Spicata Thunb. In Tropical Africa: Phytochemistry, Pharmacology, and Medicinal Potential

Maroyi

2019

Asian J Pharm Clin Res

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Cussonia spicata is an evergreen tree widely used as herbal medicine throughout its distributional range in tropical Africa. The current study is aimed at providing a critical review of the phytochemistry, pharmacology, and evaluation of the medicinal potential of C. spicata. Documented information on the phytochemistry, pharmacology, and medicinal applications of C. spicata was collected from several online sources which included BMC, Scopus, SciFinder, Google Scholar, Science Direct, Elsevier, PubMed, and Web of Science. Additional information on the phytochemistry, pharmacology, and medicinal applications of C. spicata was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the University library. This study showed that the bark, flowers, flower stalks, fruits, leaves, roots, root bark, and stems of C. spicata are used as antifebrile and emetic and herbal medicine for fever, nausea, vomiting, gonorrhea, venereal diseases, malaria, and mental illness. Phytochemical compounds identified from the leaves, root bark, stems, and stem bark of C. spicata include alkaloids, anthocyanins, anthracene glycosides, botulin, condensed tannins, free gallic acid, gallotannins, iridoids, pentacyclic triterpenoids, saponins, steroids, tannins, flavonoids, phenolics, triterpenoids, and volatile oils. Pharmacological research revealed that C. spicata crude extracts and compounds have acetylcholinesterase, antibacterial, antiviral, anti-inflammatory, antileishmanial, antiplasmodial, antiprotozoan, antioxidant, larvicidal, molluscicidal, spermicidal, and cytotoxicity activities. Future research should focus on evaluating the phytochemical, pharmacological, and toxicological properties of C. spicata crude extracts as well as compounds isolated from the species.

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