Some Items of Interest to Process R&D Chemists and Engineers

Structure–Reactivity Studies of Intermediates for Mechanistic Information by Subensemble Fluorescence Microscopy

“…These two examples bridge the areas of homogeneous and heterogeneous chemical reactivity through studying multistep, multiphase processes. Tools, applications, and results in this area of structure–reactivity studies of intermediates are new, rapidly evolving, and relevant to synthetic chemistry “users,” as well as microscopy “developers”.…”

“…Although this approach employs physical/analytical tools, the structure-reactivity answers obtained through this research are of interest to those involved in reaction design (i.e., "users" of the data rather than solely "developers" of the microscopy technique), including recently in drug discovery. 5 The purpose of this Viewpoint is to familiarize the reader with this recent direction in the field (first appearing in 2016) and is not meant to serve as a comprehensive review of subensemble fluorescence microscopy applied to chemical questions. Such reviews are available elsewhere, 6 -8 and we also provide important leading references to primary literature behind these general reviews, 9 -18 including detailed studies of the effect of the shape of nanoparticle catalysts on activity, 19 and review of other (nonfluorescent) types of subensemble microscopy as applied in chemistry 20 .…”

“…As such, it provides a new physical-organic/mechanistic toolbox for chemists interested in structure–reactivity studies of intermediates that are difficult or impossible to detect by traditional approaches. Although this approach employs physical/analytical tools, the structure–reactivity answers obtained through this research are of interest to those involved in reaction design (i.e., “users” of the data rather than solely “developers” of the microscopy technique), including recently in drug discovery …”