Some in Vitro Effects of Hypoglycin on Skin

Yardley, H.J.

doi:10.1001/archderm.1967.01610010095017

Cited by 11 publications

(3 citation statements)

References 2 publications

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“…It is first deaminated by trans- of methylenecyclopropylacetate (MCPA) rise to a maximum by 4-5 hr and then slowly decline. It is not known what proportion of hypoglycin degradation normally occurs in the liver -skin for example appears to be able to metabolise it [29] and extrahepatic tissues are a major site of branced chair amino acid catabolism. Whether MCPA can be degraded further has not been shown.…”

Section: Degradationmentioning

confidence: 99%

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Biochemistry of hypoglycin

Manchester

1974

FEBS Letters

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Hypoglycin A, P_(methylenecyclopropyl)alanine, is a non-protein amino acid first isolated [l] from the unripe fruit of the ackee, Blighia sapida, a tree much cultivated in Jamaica where the fleshy aril constitutes an important item of diet, particularly of the lower income groups. The unripe ackee aril may contain around 1 mg of hypoglycin per g wet weight and the seeds two to three times as much, but as the fruit ripens the content of the aril decreases to less than 0.01% of the amino acid [2] . Hypoglycin is found in the seeds both as the free amino acid and the y-glutamyl dipeptide conjugate, hypoglycin B

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Section: Degradationmentioning

confidence: 99%

“…Similar results have not been published for MCPA. Sherratt [29,34,35] has questioned the validity of this 'sequestration' hypothesis since a number of nonhypoglycaemic compounds can also affect intramitochondrial CoA concentrations.…”

Section: Metabolic Actionsmentioning

confidence: 99%

Biochemistry of hypoglycin

Manchester

1974

FEBS Letters

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“…The pharmacological effects of hypoglycin, namely hypoglycaemia [3], hyperketonaemia [11] and a pronounced organic aciduria [16,17], are the results of these inhibitions [8,18]. By analogy with hypoglycin, it has been suggested that MCPG is converted into a toxic metabolite, methylenecyclopropylformyl-CoA (MCPF-CoA) (Scheme 1) [2,19]. Metabolites of MCPG inhibit ,-oxidation, but at a different stage from those of hypoglycin [2].…”

Section: Introductionmentioning

confidence: 99%

Metabolic consequences of methylenecyclopropylglycine poisoning in rats

Melde

Jackson²,

Bartlett

et al. 1991

Biochemical Journal

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We describe the effects of methylenecyclopropylglycine in fasted rats. A 75% decrease in the blood glucose concentration and an increase of lactate and pyruvate were observed 6 h after administration of 100 mg of this amino acid/kg. By contrast with the effects reported for hypoglycin [Williamson & Wilson (1965) Biochem. J. 94, 19c-21c], the plasma concentrations of ketone bodies decreased after administration of methylenecyclopropylglycine and the concentrations of branched-chain amino acids in the plasma were increased 6-fold. The oxidation of decanoylcarnitine or of palmitate was nearly completely inhibited in rat liver mitochondria from methylenecyclopropylglycine-poisoned rats. The activities of acetoacetyl-CoA and of 3-oxoacyl-CoA thiolase were decreased to 25% and less than 10% of the controls. There was a pronounced aciduria, due to the excretion of dicarboxylic acids and of oxidation products of branched-chain amino acids. The accumulation of the toxic metabolite methylenecyclopropylformyl-CoA in the mitochondrial matrix was detected after administration of methylenecyclopropylglycine. Similarly we confirmed experimentally that methylenecyclopropylacetyl-CoA accumulates in mitochondria incubated with methylenecyclopropylpyruvate.

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On the mechanisms of some pharmacological actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid. A way out of the present confusion

Sherratt

Osmundsen

1976

Biochemical Pharmacology

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Some in Vitro Effects of Hypoglycin on Skin

Cited by 11 publications

References 2 publications

Biochemistry of hypoglycin

Biochemistry of hypoglycin

Metabolic consequences of methylenecyclopropylglycine poisoning in rats

On the mechanisms of some pharmacological actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid. A way out of the present confusion

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