Some histological features of canine cardiac transplants

Abstract

Some histological features of canine cardiac transplants JACQUELINE LEANDRI From the Centre d'Etudes des Technziques Chirurgicales (C.N.R.S.), Hopital Broussais, 96 Rue Didot, 75 Paris (14), France

Acute and modified rejection of heterotopic canine cardiac allotransplants studied by serial needle biopsy

“…Others have included only terminal necropsy material (Blumenstock et al, 1963;Lower, Dong, and Shumway, 1965;Leandri, 1967;Downie, 1953;Reemtsma, 1964) or give morphological changes little prominence (Reemtsma et al, 1962;Hardy et al, 1966).…”

“…In one series (Chiba et al, 1962), multinucleate giant cells resembling Aschoff cells are recorded 19 hours after transplant; these were not seen in the present study. Most agree that the end result within seven days is extensive myocardial necrosis and mononuclear cell infiltration, mainly of perivascular distribution (Reemtsma, 1964;Lower et al, 1965;Chiba et al, 1962;Rowlands et al, 1968). A pericardial and endocardial origin of the rejection process has been reported (Leandri, 1967), but the present study suggests an even distribution of the rejection process, centred on small vessels and capillaries, throughout the myocardium.…”

“…Most agree that the end result within seven days is extensive myocardial necrosis and mononuclear cell infiltration, mainly of perivascular distribution (Reemtsma, 1964;Lower et al, 1965;Chiba et al, 1962;Rowlands et al, 1968). A pericardial and endocardial origin of the rejection process has been reported (Leandri, 1967), but the present study suggests an even distribution of the rejection process, centred on small vessels and capillaries, throughout the myocardium. We feel that the changes at the pericardial surfaces are often confused by the presence of an acute inflammatory response to trauma or infection and should be ignored.…”

Canine cardiac denervation: a structural, functional, and chemical study

“…Other animals were similar to each other in lipid content. No perivascular collections of white blood cells and no loss of striations, which accompany autotransplantation according to Leandri (1967), were found in the complete extrinsic cardiac denervated dogs of the present study (Figures 112 and 115). Measurements of intimai, medial, and adventitial thickness, because the vessels varied in size, were reported in ratio of medial and of adventitial thickness to the intimai thickness.…”

“…Were being re-established if immunochemical factors were not deterrents. Leandri (1967) Dong, Fowkes, Hurley, Hancock, and Pillsbury (1964) eighteen to twenty-three months after autotransplantation, found that the atrial pacemakers governed cardiac rhythm, that there was vagal and sympathetic reinnervation of the heart, and that there was no evidence of congestive heart failure. The major aspects of cardiac control and myocardial performance were viewed as normal.…”