Some Histochemical Observations on the Human Eccrine Sweat Glands

Giant Centrifugal Miliaria Profunda

“…It was clear that extravasation of blocked sweat into the skin at different levels produced the various forms of miliaria, but the primary cause of obstruction remained a mystery. A PAS-positive material had been demonstrated in the ducts in some cases of experimentally induced miliaria (6) and in anhidrotic lesions of psoriasis and other chronic dermatoses (8). The studies of Holzle and Kligman (1) suggested that this material represented the primary obstruction.…”

“…In 1956, however, Hambrick and Blank (5) failed to demonstrate the homy plugs in microscopic studies of miliaria crystallina. In addition, Dobson et al (6) in 1957 produced anhidrosis by freezing the skin, but homy plugs were not demonstrable microscopically. The freezing caused degeneration of the sweat duct and as this damage was repaired, parakeratotic plugs appeared, indicating that these represent a late event and part of the repair process rather than the primary cause of the obstruction.…”

“…The nature of this PAS-positive material is unclear. Dobson et al (6) thought it had its origin in the secretory cells of the sweat coil, while Holzle and Kligman (1) considered it to derive from the cytoplasm of sweat duct iuminal cells, whose cell membranes have been rendered more permeable by toxins from the bacteria that are significantly increased in numbers on skin whose stratum corneum is overhydrated by sweating. After four days of occlusion in Holzle and Kligman's study (1), the amorphous material was intermingled with inflammatory cells, which subsequently degenerated, forming a firm plug that was still evident one week after the occlusion had ceased.…”

Activation of chloride secretion via proteinase‐activated receptor 2 in a human eccrine sweat gland cell line – NCL‐SG3

“…They consist of (i) a secretory coil and (ii) a reabsorptive duct that opens directly to the skin surface. The secretory coil, produces a sodium chloride solution isotonic to plasma, from which sodium chloride is reabsorbed in the duct, thereby providing at the skin surface a sweat hypotonic with respect to plasma [see reviews (19)(20)(21)]. The production of human sweat from the secretory coil involves the secondary active transport of chloride (Cl ) ) and sodium (Na + ) ions across the secretory epithelium into the sweat gland lumen, creating an osmotic gradient for the transepithelial movement of water (22)(23)(24)(25)(26)(27)(28)(29).…”

Die Rolle der Schweiβ-Sekretion beim atopischen Ekzem im Kindesalter

“…Einige Autoren vertreten die Ansicht, daß cs sich um eine Verteilungsstörung der Schweiß antw ort und ihrer Nervenregulation handelt [25], (Beugenhyper hidrose bei der Neurodermitis) [26]; andere nehmen an, daß es durch sofortiges Einsaugen des ausgeschiedenen Schweißes in die H aut oberfläche am O rte des zukünftigen pathologischen Prozesses zu scheinbarer Hypohidrose kommt. Verminderte Talgmenge und er höhte Benetzungsfähigkeit könnten Verschluß der Schweißporen durch Quellung hervorrufen [27,28,29,30]. Es fehlt auch nicht die Ansicht, daß die so verursachte Schweißretention sich irgendwie an der E ntstehung des weißen Dermographismus [2,31] Um festzustcllen, ob die Hyperhidrose der neurodermitischen Hautmorphe ebenso wie die ekkrine Schweiß-Sekretion auf der gesunden Haut durch Atropin inhibiert wird, haben wir folgenden Versuch durchgeführt:…”