Some Highlights of Virus Research in 1990

Elliott, Richard M.; Crook, Norman E.; Desselberger, Ulrich; Hull, Roger; McGeoch, Duncan J.

doi:10.1099/0022-1317-72-8-1761

Journal of General Virology

1991

DOI: 10.1099/0022-1317-72-8-1761

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Some Highlights of Virus Research in 1990

Richard M. Elliott

Norman E. Crook

Ulrich Desselberger

et al.

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1993

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Cited by 2 publications

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“…Eukaryotes are known to have most of their translated nuclear genes split into coding (exon) and noncoding (intron) sequences (44). It is predicted that HCMV may also encode many spliced genes (17), as do a number of other herpesviruses (1,40). Currently, only 12 of the ORFs of HCMV have been shown to be spliced; 3 differentially at IE times (29, 51, 58) and 2 at early times (60).…”

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confidence: 99%

Spliced transcripts of human cytomegalovirus

Rawlinson

Barrell

1993

J Virol

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The availability of the human cytomegalovirus (HCMV) genomic sequence has resulted in more extensive knowledge of the overall coding capacity of the virus. Using polymerase chain reaction and rapid sequencing techniques, we have studied the splicing of mRNAs from a number of the predicted open reading frames (ORFs). Splicing was found between the UL122(IE2) ORF present within major immediate-early (MIE) region 2 and the downstream ORF (UL118) predicted to encode an incomplete glycoprotein. This locates the IE2 3' donor site and provides evidence of a link between the MIE region and downstream ORFs. The downstream UL119-UL118-UL115 ORFs also undergo differential splicing, further increasing the known complexity of this region of the genome. A detailed map of the differential splicing within the region encoding the MIE ORF is presented. Also described are several previously unidentified spliced ORFs found in the long repeats and long unique regions, including one encoding a transcript with a large (4-kb) intron. The results show that spliced transcripts are encoded from throughout the genome at immediate-early, early, and late times postinfection.

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confidence: 99%

Spliced transcripts of human cytomegalovirus

Rawlinson

Barrell

1993

J Virol

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Some highlights of virus research in 1989

Elliott

Hull

McGeoch

1990

Journal of General Virology

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Some Highlights of Virus Research in 1990

Cited by 2 publications

References 73 publications

Spliced transcripts of human cytomegalovirus

Spliced transcripts of human cytomegalovirus

Some highlights of virus research in 1989

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