Some heteroleptic boron derivatives and their isomers derived from Schiff bases and glycol: synthesis, characterization and antimicrobial activities

Abstract

Some new heteroleptic boron derivatives of the type OCH 2 C(CH 3 ) 2 CH 2 OBO(CH 3 )C:CHC(R):N(R′)OH [where R = CH 3 , R′ = (CH 2 ) 2 (2a); (CH 2 ) 3 (2b); CH(CH 3 )CH 2 (2c), R = C 6 H 5 , R′ = (CH 2 ) 2 (2d); (CH 2 ) 3 (2e); CH(CH 3 )CH 2 (2f)] have been synthesized by the reactions of tri-isopropyl borate with bifunctional tridentate Schiff bases and 2,2-dimethyl propane 1,3-diol in 1:1:1 molar ratio in refluxing benzene. Four isomers of corresponding heteroleptic derivatives 2a, 2b, 2e and 2f having the general formula OCH 2 C(CH 3 ) 2 CH 2 OBO(R′)N:C(R)CH:C(CH 3 )OH[where R = CH 3 , R′ = (CH 2 ) 2 (3a); (CH 2 ) 3 (3b), R = C 6 H 5 , R′ = (CH 2 ) 3 (3e); CH(CH 3 )CH 2 (3f) have also been synthesized by adopting different synthetic two-step processes. All these compounds have been characterized by elemental analyses, and their tentative structures have been proposed on the basis of IR, 1 H, 13 C, 11B NMR spectroscopic and FAB mass spectrometric studies. Schiff base ligands and their corresponding heteroleptic boron derivatives (2a-f) have also been screened for antimicrobial activities against pathogenic bacteria and fungi.

Synthesis of cis‐1,2‐diol‐type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation

“…[6][7][8] Because of the aforementioned reasons, starting from relatively simple reagents, dioxaborinane complexes containing an N ! B dative bond have successfully been developed including fluorescence, [9] electrochemical, [10] enzymebased sensing, [11] pharmaceutical applications, [12,13] catalytic applications, [14][15][16][17] antioxidant and antimicrobial applications [18][19][20][21][22][23][24] etc.…”

Some Novel Dinuclear phenylboronates of biologically potent β‐enaminoesters: Synthesis, Spectroscopic characterization, antimicrobial activity and their antiandrogenic effect

“…In view of the above, we report in this article the synthesis and characterization of monomeric phenylboronates of β‐enamino esters. The proclaimed biological activities of organoboron compounds led us to investigate the antimicrobial activities of these phenylboronates. The antimicrobial activities of these boron compounds have been compared with phenyl boronic acid and corresponding ligands.…”

“…The chemistry of organoboron compounds has been investigated for the last two decades owing to their antifungal, antibacterial, and antifertility activities . Organo‐boron compounds of β‐diketones, Schiff bases, 8‐hydroxyquinoline and pyridyl phenol have been reported in the literature due to their potential applications in OLED, catalysis, organic synthesis, cancer therapy and medicinal chemistry .…”