Some Hematological and Biochemical Changes Associated with Aspirin Administration in Albino Rats = بعض التغيرات الدموية و البيوكيميائية المصاحبة لإعطاء الأسبرين في الجرذان البيضاء

Abdel-Aziz, Ismail; Elyazji, Nehad R.; Ashour, Abdelrahiem A.

doi:10.12816/0027942

Cited by 1 publication

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References 9 publications

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“…Blood samples were collected to examine fragility profile and osmotic resistance. Aspirin was administered orally for leukocytopenia induction, with 150 mg/kg administered daily for 6 days a week for 5 weeks (17). Heparin was subcutaneously administered for thrombocytopenia induction, with platelet count confirmation after ten days (18).…”

Section: Induction and Confirmation Of Anaemia Leukocytopenia And Thr...mentioning

confidence: 99%

Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Oghogho Okporu,

John C. Igweh,

Oyovwi O. Mega

2023

Int. J. Sci. Res. Arch.

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Background: Caffeine and Vitamin C, key component in foods and beverages, have been investigated for potential haematological disease prevention. Aim: To lend credence to the above studies, the current study in Wistar rats evaluated the effects of caffeine and vitamin C in the management of haematological disorders in rats. Methods: Experimental animals were divided into three experimental phases (anaemic, leukocytopenic, and thrombocytopenic phases). Interventions with caffeine and vitamin C during anaemic, leukocytopenic, and thrombocytopenic phases were initiated for two weeks. Haematological parameters were all tested. All test, statistics were run using the Graph Pad Prism 8.1 at a confidence level of 0.05 or less (p-value). Results: After analysis, caffeine and vitamin C shows a significant increase in RBC, PCV, Hb count in the anaemic treated rats when compared to control. Similarly, there was a significant increase in platelet count in the thrombocytopenic treated rats when compared to untreated thrombocytopenic group. There was also a significant increase in monocyte, lymphocyte and neutrophil counts in leukocytopenic animals compared to luukocytopenic group untreated. Conclusion: In conclusion, this study suggests that caffeine and vitamin C have haemoprotective effects against anaemic, leukocytopenic and thrombocytopenic conditions.

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Section: Induction and Confirmation Of Anaemia Leukocytopenia And Thr...mentioning

confidence: 99%

Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Oghogho Okporu,

John C. Igweh,

Oyovwi O. Mega

2023

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

show abstract

Some Hematological and Biochemical Changes Associated with Aspirin Administration in Albino Rats = بعض التغيرات الدموية و البيوكيميائية المصاحبة لإعطاء الأسبرين في الجرذان البيضاء

Cited by 1 publication

References 9 publications

Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

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