Some haematological parameters of tuberculosis infected Nigerians: A study in Calabar - Nigeria

Abstract

Tuberculosis is a major public health problem in Nigeria. Drug resistant tuberculosis is now common place due to poor patient compliance and lack of detection of resistant strains. The occurrence of HIV has been responsible for an increased frequency of tuberculosis. Knowledge of the blood picture in pulmonary tuberculosis, is believed, will be a valuable tool in the management of patients. This study aimed at providing information on haematological changes in pulmonary tuberculosis. A total of 200 subjects were investigated. One hundred of these were pulmonary tuberculosis patients comprising 62 males and 38 females who attended the University of Calabar Teaching Hospital and the Dr. Lawrence Henshaw Memorial Hospital (Infectious Diseases Hospital), Calabar, Cross River State; while the remaining 100 were non-pulmonary tuberculosis subjects comprising 50 males and 50 females who served as control subjects. Standard techniques were used for the assays. Routine haematological analyses were carried out which included Packed Cell Volume, Haemoglobin concentration, Mean Cell Volume, Mean Cell Haemoglobin, Erythrocyte Sedimentation Rate, Platelet and Total White Blood Cell counts. Age and gender were also evaluated in the enrolled subjects. Results showed significantly lower values (p<0.05) for Packed cell volume, haemoglobin concentration and mean cell haemoglobin concentration in pulmonary tuberculosis patients than in control subjects while mean cell volume and erythrocyte sedimentation rate showed significantly higher values in pulmonary tuberculosis patients than in control subjects. Packed cell volume, Haemoglobin concentration, Mean Cell Volume, Mean Cell Haemoglobin, and Erythrocyte Sedimentation Rate of pulmonary tuberculosis patients co-infected with HIV were significantly affected (p<0.05). The highest prevalence rate of infection (60%) occurred in the age group (10-30) years. In conclusion, the study showed that tuberculosis had significant effects on the haematological parameters analysed which were in turn aggravated in co-infection with HIV.

Assessment of Haematological Parameters of Pulmonary Tuberculosis Patients with and Without HIV Infection Attending Two Secondary Health Facilities in Jigawa State

“…High ESR values were found in both PTB and PTB/HIV co-infected patients (44.45±0.71 and 52.57±3.12) with 64% of the whole study population having high ESR values. 44.45mm/hr and 52.57mm/hr values are lower when compared with research conducted in Calabar, Nigeria with the mean ESR values of 104.2mm/hr [23], Ludhiana city, India by [28] who found 66.86mm/hr ESR values among TB patients and 64.3mm/hr found in Pakistan by [29]. 64% is also low when compared with the result of [16] who recorded 93.33% of the TB patients having high values above the normal range.…”

“…The result showed a statistically significant higher platelet count in PTB/HIV patients when compared to PTB/HIV co-infected patients (317±0.98 versus 291±0.03). The finding is supported by studies in Babylon province and Kirkuk city, Iraq [21,22], and Pakistan [19], and the values are higher when with 111.9 recorded in Calabar, Nigeria [23]. Also 30% of the study population have high platelets count, this was lower when compared with studies conducted in Dhaka, Bangladesh with 80% [16] and East London by Morris et al, 1989, that recorded 52% elevated platelet count, and the result is higher when compared with 8% in Hungary [24].…”

Biochemical profiling of tuberculosis patients co-infected with hepatitis C virus

“…We also found an elevation in the ESR of the Test group. Our results therefore coincide with the findings of Okafor et al 20 as they also reported an elevation in the ESR of TB patients rather than that of control participants.…”

Effect of pulmonary tuberculosis on natural anticoagulant activity in therapy-naïve Ghanaian adults; a case-control study

“…These ndings were consistent with some recent studies [21,35], but contrasting to ndings of other studies from Nigeria by Akpan et al [44] and Okafor et al [45], plausibly because their studies recruited subjects with heterogeneous ages that encompassed both children and adults whereas we considered entirely adults.…”