Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro

Christen, Verena; Crettaz, Pierre; Oberli-Schrämmli, Aurelia; Fent, Karl

doi:10.1016/j.chemosphere.2010.09.031

Cited by 107 publications

(72 citation statements)

References 61 publications

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“…TBBPA showed in vitro androgenic, antiandrogenic and anti-estrogenic activities, but no estrogenic activity as shown in Table 3, which is consistent with the previous studies (Kitamura et al, 2005;Christen et al, 2010; Fig. S4 and Fig.…”

Section: Changes In Hormonal Activitiessupporting

confidence: 91%

Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A

et al. 2014

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Section: Changes In Hormonal Activitiessupporting

confidence: 91%

Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A

et al. 2014

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“…HBCYD was tested for its androgenic and antiandrogenic activity in vitro in the MDA-kb2 cell line (Christen et al, 2010). It enhanced the dihydrotestosterone dependent activation of the androgen receptor-responsive gene expression to maximally 150 %, but it exhibited no agonistic activity.…”

Section: Hazard Identificationmentioning

confidence: 99%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

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“…Although the endocrine disrupting effect of the biocide TCS has been well documented, and also found at high concentrations in the environment (Table 1, Halden and Paull, 2005), limited data are available on the endocrine-disrupting effect of TCC. Exposure to TTC in human cell-based bioassays, and exposure of rodents to TTC, indicated that the biocide does not have endocrine-disrupting activity on its own, but rather enhances the action and binding affinity of steroid hormones (Table 2; Ahn et al, 2008;Chen et al, 2008;Christen et al, 2010;Yueh et al, 2012). This shows a potentiating mechanism of endocrine disruption, as well as an alternative mode of endocrine disruption other than direct modulation of endocrine pathways.…”

mentioning

confidence: 99%

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

Archer

Wolfaardt

Wyk

2017

WSA

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Globally, water resources are under constant threat of being polluted by a diverse range of man-made chemicals, and South Africa is no exception. These contaminants can have detrimental effects on both human and wildlife health. It is increasingly evident that several chemicals may modulate endocrine system pathways in vertebrate species, and these are collectively referred to as endocrine disrupting contaminants (EDCs). Although the endocrine-disrupting effect of water pollutants has been mainly linked to agricultural pesticides and industrial effluents, other pollutants such as pharmaceuticals and personal care products (PPCPs) are largely unnoticed, but also pose a potentially significant threat. Here we present for the first time in a South African context, a summarised list of PPCPs and other EDCs detected to date within South African water systems, as well as their possible endocrine-disrupting effect in-vitro and in-vivo. This review addresses other factors which should be investigated in future studies, including endocrine disruption, PPCP metabolites, environmental toxicology, and antibiotic resistance. The challenges of removing EDCs and other pollutants at South African wastewater treatment works (WWTWs) are also highlighted. The need for focused research involving both in-vitro and in-vivo studies to detect PPCPs in water systems, and to delineate adverse outcome pathways (AOPs) of priority PPCPs to aid in environmental impact assessment (EIA), are discussed.

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Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro

Cited by 107 publications

References 61 publications

Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A

Ferrate(VI) oxidation of tetrabromobisphenol A in comparison with bisphenol A

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

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