Some Features of Cytokine Status in Patients With Psoriasis

Abstract

The purpose of the study is to evaluate the content of IL‑7, –4 and –17A in the blood of patients with psoriasis, depending on the severity of the disease. Materials and methods. A group of patients was examined, which included 47 patients with vulgar psoriasis; 10 patients with arthropathic psoriasis, as well as a control group of 15 conditionally healthy individuals. The content of interleukin –4, –7, –17A was determined in blood serum by the immunoenzymatic method. Results and conclusions. In patients with a severe course of psoriasis (arthropathic psoriasis), pathological activation of hereditary and acquired (Th1- and Th17-types) immunity is observed, there is a dysregulation of the synthesis of pro-inflammatory (IL‑17) and anti-inflammatory (IL‑4) cytokines. Detection of disturbances in the levels of mediators of the immune response, which are involved in the formation of immune inflammation, in particular cytokines, in patients with psoriasis can serve as an additional test for predicting the clinical course of this dermatosis.