Some Factors Affecting the Microencapsulation of Pharmaceuticals with Cellulose Acetate Phthalate

Beyger, Joseph W.; Nairn, J. Graham

doi:10.1002/jps.2600750610

Cited by 37 publications

(12 citation statements)

References 10 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microspheres were prepared by a new solvent evaporation method, that has contributions from the methods reported by Beyger and Nairn (1986), and by Manekar et al (1992).…”

Section: Preparation Of Cap Microspheresmentioning

confidence: 99%

Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method

Silva

Ferreira²

1999

Journal of Microencapsulation

View full text Add to dashboard Cite

Drugs with different water-solubility and molecular weights were microencapsulated in cellulose acetate phthalate, using an emulsion-solvent evaporation technique with a continuous oil-phase. The mean size of the particles was approximately 600 microns, and they were non-porous. The capacity of the microspheres to retain the drugs was evaluated by in vitro release studies in acidic medium. For low molecular weight compounds the release rates increased with solubility: for thiamin hydrochloride and phenacetin, a highly and a poorly soluble compound respectively, the percentages released at 60 min were 90 and 10%. Drugs with molecular weights above approximately 700 Da were retained in the microspheres. The above dependence on solubility was corroborated by release studies in ethanol, and by modelling the release of phenacetin in acidic media. Microspheres with a different polymer matrix, Eudragit RS PO, were also prepared by a similar technique, and these particles prolonged the release of thiamin for over 6 h, under simulated GI conditions.

show abstract

“…The microspheres were prepared by a new solvent evaporation method, that has contributions from the methods reported by Beyger and Nairn (1986), and by Manekar et al (1992).…”

Section: Preparation Of Cap Microspheresmentioning

confidence: 99%

Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method

Silva

Ferreira²

1999

Journal of Microencapsulation

View full text Add to dashboard Cite

show abstract

“…To prevent the aggregation of soft microspheres formed at the initial stage, Span 80 was added as a dispersant to improve the dispersibility and prevent the aggregation (Beyger and Nairn 1986).…”

Section: Resultsmentioning

confidence: 99%

Preparation of enteric-coated microspheres of Mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate: The effect of swine serum on micromeritic properties

et al. 1991

View full text Add to dashboard Cite

Cellulose acetate phthalate was used to prepare the Mycoplasma hyopneumoniae vaccine (MHV) microspheres using a solvent evaporation method. Swine serum was used as an additive in the antigen to form the core materials.The addition of serum had a significant effect on surface topography of the MHV lnicrospheres.By using this modified solvent evaporation method, the recoveries of antigens in the MHV microspheres were generally over 90% of the weight and antigenicity of antigens originally added in the formulation.

show abstract

“…The preparation of microparticles with enteric polymers forming the matrix offers the potential for pH-controlled release without the need for enteric coating (Beyger and Nairn 1986;El-Said and Hashem 1991). Palmieri and co-workers (Palmieri et al 2002) demonstrated this concept by spray-drying enteric polymers and drug (ketoprofen) from ammonia solution.…”

Section: Matricesmentioning

confidence: 98%

Cellulose esters in drug delivery

Edgar

2006

Cellulose

167

View full text Add to dashboard Cite

Cellulose esters have played a vital role in the development of modern drug delivery technology. They possess properties that are not only well-suited to the needs of pharmaceutical applications, but that enable construction of drug delivery systems that address critical patient needs. These properties include very low toxicity, endogenous and/or dietary decomposition products, stability, high water permeability, high T g , film strength, compatibility with a wide range of actives, and ability to form micro-and nanoparticles. This suite of properties has enabled the creation of a wide range of drug delivery systems employing cellulose esters as key ingredients. The following is a review of the most important types of these systems, and of the critical roles played by cellulose esters in making them work, focusing on more recent developments.

show abstract

Some Factors Affecting the Microencapsulation of Pharmaceuticals with Cellulose Acetate Phthalate

Cited by 37 publications

References 10 publications

Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method

Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method

Preparation of enteric-coated microspheres of Mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate: The effect of swine serum on micromeritic properties

Cellulose esters in drug delivery

Contact Info

Product

Resources

About