Some experience with deglycyrrhizinated liquorice in the treatment of gastric and duodenal ulcers with special reference to its spasmolytic effect.

Treatment of Duodenal Ulcer with Glycyrrhizinic-acid-reduced Liquorice: A MULTICENTRE TRIAL

“…In both comparable groups of patients the symptoms declined progressively during the course of treatment, indicating that the observations probably document the natural evolution of an attack of duodenal ulcer under outpatient management. The present data are in agreement with those of Feldman and Gilat (1971), but do not confirm the beneficial effect on symptoms of duodenal ulcer reported by others on the basis of controlled observations on a total of 70 patients treated for two or four weeks (Tewari and Trembalowicz, 1968;Mills and Mamrau, 1969). The dose used by these workers was the same as in the present series, but a commercially available tablet (Gaved-S) was prescribed which, in addition to 380 mg of glycyrrhizinic-acid-reduced liquorice, contained bismuth subnitrate 100 mg, colloidal aluminium hydroxide 100 mg, magnesium carbonate 200 mg, sodium bicarbonate 100 mg, and frangula 30 mg.…”

“…Preparations of glycyrrhizinic-acid-reduced liquorice have been reported to increase the rate of healing of gastric ulcer (Russell and Dickie, 1968;Turpie et al, 1969) and to be effective in the treatment of duodenal ulcer (Tewari and Trembalowicz, 1968;Mills and Damrau, 1969). The purpose of the therapeutic trial reported here was further to determine whether treatment with glycyrrhizinic-acid-reduced liquorice has a beneficial effect on the symptoms of duodenal ulcer.…”

Clinical trial of deglydyrrhizinized liquorice in gastric ulcer.

“…Gassman and Forster (1963) found no evidence of salt and water retention in their patients receiving this drug. Tewari and Trembalowicz (1968) reported no electrolyte disturbance, pitting oedema, or rise in blood pressure in a small series of patients treated with Caved-(S). In a trial of Caved-(S) in patients with gastric and duodenal ulcers, Russell and Dickie (1968) found no evidence of fluid retention or electrolyte upset.…”

A trial of deglycyrrhizinated liquorice in the treatment of duodenal ulcer

“…An effect was noted in the gastric ulcer patients, while in duodenal ulcer patients the difference in the clinical improvement between the treated group and the control group 'was not statistically significant'. Tewari and Trembalowicz (1968) reported excellent results in 48 patients with duodenal ulcer and in six patients with gastric ulcer in a double-blind trial. The clinical effect is reported for both ulcer types together.…”

“…To avoid the sodium and fluid retention caused by whole liquorice extract and carbenoxolone, the latter was eliminated and a new preparation, deglycyrrhizinated liquorice (Caved-S) introduced. It did not cause sodium or fluid retention and was reported to be active in gastric ulcer (Tewari and Trembalowicz, 1968;Russell and Dickie, 1968), and more interestingly in duodenal ulcer in which carbenoxolone was not proved to be effective (Doll et al, 1962;Cliff and Milton-Thompson, 1970). In this article we report a double-blind trial of de-Received for publication 23 March 1971. glycyrrhizinated liquorice (Caved-S) in patients with duodenal ulcer.…”