Some Epidemiological Aspects of Cirrhosis of the Liver

Lilienfeld, Abraham M.; Korns, Robert F.

doi:10.1093/oxfordjournals.aje.a119410

Cited by 14 publications

(10 citation statements)

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“…Low socioeconomic status based on composite index and low family income would imply a low standard of living with an increased likelihood of dietary insufficiency, particularly a lack of lipotropic substances, and probably more frequent infections, both of which may synergistically interact with the toxic effect of alcohol in the pathogenesis of cirrhosis of the liver. The fact that the mortality rate from cirrhosis of the liver is greatest in the lowest socioeconomic class in Pennsylvania is consistent with the data for the United States pertaining to the occupational level (15), the Buffalo data regarding the four economic quarters (14), and with the results of the California study (19).…”

Section: Discussionsupporting

confidence: 85%

“…The major objective of this study was to analyze cirrhosis mortality data pertaining to Pennsylvania in reference to some of the epidemiologic views expressed, particularly by Jolliffe and Jellinek, Lilienfeld and Korn, and Terris (13)(14)(15) …”

Section: Objectivementioning

confidence: 99%

“…Leevy and Baker (9) stated that many chronic alcoholics with overt stigmata of malnutrition exhibit normal liver structure and function; thus factors as yet undefined detennine susceptibility of certain alcoholics to fatty liver. Other (14) on the ground that the existing evidence was not sufficient to support such a definite cause-and-effect relationship* they maintained, rather, that the association between alcoholism and cirrhosis might be of an indirect nature, and that certain other factors, such as industrial hazards, metabolic and nutritional abnonnalities, and fatty degeneration might play a role in the pathogenesis of this disease. In 1967 Terris (15) provided further statistical evidence to support the view expressed earlier by Jolliffe and Jellinek (13), stating that per capita consumption of alcohol was directly related to the number of persons having cirrhosis of the liver.…”

mentioning

confidence: 99%

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Alcohol Sales and Socioeconomic Factors Related to Cirrhosis of the Liver Mortality in Pennsylvania

Tokuhata¹,

Digon²,

Ramaswamy³

1971

HSMHA Health Reports

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Section: Discussionsupporting

confidence: 85%

Section: Objectivementioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Alcohol Sales and Socioeconomic Factors Related to Cirrhosis of the Liver Mortality in Pennsylvania

Tokuhata¹,

Digon²,

Ramaswamy³

1971

HSMHA Health Reports

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“…This would appear to be a rather fertile field for epidemiological investigation by those engaged in industrial hygiene. With cirrhosis mortality climbing each year to higher levels in the United States, such an investigation is necessary, particularly since it might reveal certain practical control measures (Lilienfeld & Korns, 1950).…”

Section: Cirrhosis Of the Livermentioning

confidence: 99%

The post‐repeal eclipse in knowledge about the harmful effects of alcohol

Katcher

1993

Addiction

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National Prohibition in the USA (1919 to 1933) was followed by an era in which medical scientists played an important role in minimizing the harmful effects of alcohol. Cirrhosis, cardiomyopathy, adverse fetal effects, and esophageal cancer are examples of alcohol-related health problems that were well known at the beginning of the 20th century but were dismissed during the late 1930's and early 1940's, only to be rediscovered during the 1960's and afterwards. This eclipse in knowledge occurred because of skepticism about earlier claims that had been made in the name of scientific temperance and, most importantly, because of changing standards for medical evidence. The paradigm for disease causation that gave birth to modern medicine was based on microbiology and reinforced by hormone and nutrition discoveries. Most alcohol-related health problems are poorly explained by this paradigm. The more recent epidemiologic paradigm for noninfectious disease is more applicable to the health risks associated with heavy drinking. A transformation of knowledge about alcohol's relationship to disease has occurred.

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“…A key epidemiological paper published by Lilienfeld & Korns (1950) proposed that cirrhosis mortality was more strongly associated with industrial toxins and urbanization than with alcohol consumption. The paper criticized the trend data on cirrhosis and alcohol consumption presented by JoUiffee & Jellinek (1941) arguing that the apparent correlation between the two variables was really an artifact of physicians' reporting practices during Prohibition.…”

Section: Cirrhosis Epidemiologymentioning

confidence: 99%