Some Enzymes of Glucose Metabolism in the Human Fetus

Hahn, Peter; Skala, Judith A.

doi:10.1159/000240294

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…During this period of active fetal growth when glucose is the main source of energy, there seems to be an increase in the enzymes of glycolysis in the brain (Hahn and Skala, 1970). During that interval, phosphofructokinase undergoes a fivefold increase in cerebral cortex, but does not change in the placenta or the liver.…”

Section: Normal Growth Patterns and Body Compositionmentioning

confidence: 99%

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Association of Fetal Growth with Maternal Nutrition

Metcoff

1978

Principles and Prenatal Growth

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Section: Normal Growth Patterns and Body Compositionmentioning

confidence: 99%

“…Addition of cyclic AMP to the in vitra study system increases the activities ofthese enzymes by 35-50%. In the fetus, the liver is more of a receiver than a giver, according to Hahn and Skala (1970).…”

Section: Normal Growth Patterns and Body Compositionmentioning

confidence: 99%

Association of Fetal Growth with Maternal Nutrition

Metcoff

1978

Principles and Prenatal Growth

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“…Surprisingly enough, the literature supplies scanty information on the behavior of the glycolytic group enzymes in human fetus [14]. H a h n and S k a l a found in their study [5] that pyruvate kinase activity in fetuses aged 10-20 weeks was most pronounced in the muscles and brain. The activity in these organs seemed to increase with age.…”

Section: Discussionmentioning

confidence: 99%

Pentose Phosphate Pathway of Erythrocytes in Infancy

1971

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“…The activity of this enzyme in human fetal liver has been described [10]. Values in fetal kidney are about 4 times higher than those in the liver (Fig.…”

Section: Enzyme Activities In Human Fetal Liver and Kidneymentioning

confidence: 97%

Enzyme Induction in Human Fetal Liver

Kirby

Hahn

1973

Pediatr Res

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ExtractFetal liver obtained from legal abortions was cultured in vitro. The activities of pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (GPD), phosphoenolpyruvate carboxykinase (PEPK), and tyrosine transaminase (TTA) were determined immediately after abortion and after culturing for 24 hr. Changes due to culturing were the following: a loss in protein content (-45%), a decrease in PK ( -16%) and GDP (-40%) activities, a rise in PEPK activity ( + 180%) and, a fall in TTA activity (-10%) in fetuses younger than 16 weeks and a rise in older fetuses (+60%).Dibutyryl cyclic AMP (DcAMP) added to the cultures for the last 5 hr of incubation raised the activities of PEPK and TTA by 35% and 50%, respectively. Addition of oleic acid together with DL-carnitine had the same effect on PEPK only (+35%). PEPK activity was found to be increased 10-fold in a 12.5-week-old fetus, the mother of whom had been receiving prednisolone.It was also found that TTA and cytoplasmic PEPK activities decrease with increasing fetal age. SpeculationOur data indicate that it is possible to induce TTA and PEPK very early in fetal life. It is hence possible that certain drugs and hormones applied to the mother have an effect on liver enzyme systems in the young fetus. It seems important to establish whether such induced changes have a deleterious effect on further fetal development.

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Some Enzymes of Glucose Metabolism in the Human Fetus

Cited by 12 publications

References 5 publications

Association of Fetal Growth with Maternal Nutrition

Association of Fetal Growth with Maternal Nutrition

Pentose Phosphate Pathway of Erythrocytes in Infancy

Enzyme Induction in Human Fetal Liver

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