Some Effects of Methionine on the Utilization of Nitrogen in the Adult Dog

Allison, J. B.; Anderson, John A.; Seeley, R.

doi:10.1093/jn/33.4.361

Cited by 63 publications

(14 citation statements)

References 7 publications

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“…However, supplementation with methionine to the protein-free diet alleviated body weight loss by 6 g/day, which was in good agreement with the nitrogen-sparing effect of dietary methionine extensively studied in several mammalian species (Allison et al 1947;Lubaszewska et al 1973;Yoshida & Moritoki 1974;Yokogoshi & Yoshida 1976;Yokogoshi et al 1977) and chickens (Okumura & Muramatsu 1978a,b;Muramatsu & Okumura 1979a,b,c, 1980a. During 2 days of protein starvation before feeding various experimental diets, chickens lost 37.0 g body weight, and successive feeding of the protein-free diet for a further 2 days, an additional 22.0 g of body weight was lost.…”

Section: Discussionsupporting

confidence: 84%

“…The supplementation of methionine in a protein-free diet had a nitrogen-sparing effect leading to the reduction of urinary nitrogen excretion in rats (Yoshida & Moritoki 1974;Yokogoshi & Yoshida 1976;Yokogoshi et al 1977), dogs (Allison et al 1947) and pigs (Lubaszewska et al 1973). However, nutritionally these amino acids can be divided into two categories: those that animals cannot synthesize at all or not enough for metabolic requirements (essential) and those that can be synthesized from other amino acids (nonessential).…”

Section: Introductionmentioning

confidence: 99%

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Alleviation of body weight loss by dietary methionine is independent of insulin‐like growth factor‐I in protein‐starved young chickens

Nagao

Oki

Tsukada

et al. 2011

Animal Science Journal

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It is well known that in protein-starved chickens, small amounts of amino acid supplement, especially methionine, reduces nitrogen excretion and thereby improves nitrogen balance. On the other hand, excess intake of methionine causes growth depression and the growth-depressive effect of excess methionine can be alleviated by consumption of dietary glycine. Insulin-like growth factor-I (IGF-I) is one of various growth-promoting factors relating to the efficiency of animal production and is known to be very sensitive to changes in nutritional status. In the present study, the interactive effect of glycine on nitrogen sparing effect of methionine in protein-starved chickens was examined. In addition, the relation of IGF-I and its specific binding protein to the nitrogen sparing effect of supplemented methionine was also investigated. Two-days refeeding of methionine supplemented to protein-free diet could promptly alleviate body weight loss in protein-starved chickens, and the alleviation of body weight loss by methionine was not improved by glycine supplements. Moreover, such acute alleviation of body weight loss by dietary methionine was independent of the change in plasma IGF-I concentration.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Alleviation of body weight loss by dietary methionine is independent of insulin‐like growth factor‐I in protein‐starved young chickens

Nagao

Oki

Tsukada

et al. 2011

Animal Science Journal

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“…Several investigators have reported that methionine supplementation of a protein-free diet reduces body weight loss and improves nitrogen balance in rats (13), chickens (14), pigs (15), and dogs (16). Our own work (17) has confirmed the earlier suggestion (18) that the methionine response is not due to methionine per se but instead to methionine furnishing sulfur for cysteine biosynthesis via transsulfuration.…”

Section: Questionssupporting

confidence: 82%

Comparative nutrition and metabolism: Explication of open questions with emphasis on protein and amino acids

Baker

2005

Proc. Natl. Acad. Sci. U.S.A.

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The 20th century saw numerous important discoveries in the nutritional sciences. Nonetheless, many unresolved questions still remain. Fifteen questions dealing with amino acid nutrition and metabolism are posed in this review. The first six deal with the functionality of sulfur amino acids (methionine and cysteine) and related compounds. Other unresolved problems that are discussed include priorities of use for amino acids having multiple functions; interactions among lysine, niacin and tryptophan; amino acid contributions to requirements from gut biosynthesis; the potential for gluconeogenesis to divert amino acids away from protein synthesis; the unique nutritional and metabolic idiosyncrasies of feline species, with emphasis on arginine; controversies surrounding human amino acid requirements; and the potential for maternal diet to influence sex ratio of offspring.amino acid deficiency ͉ sulfur amino acids ͉ arginine ͉ lysine ͉ niacin

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“…At very low levels of dietary protein, the BVs of both wheat gluten and lactalbumin were more than 100, apparently because when the dietary level of proteins was low urinary N excretion exceeded the endogenous level. Nitrogen sparing effects were also observed with 3.5% egg protein diet (12) and methionine supplemented protein-free diet (13). YOSHIDA and MORITOKI (14) demonstrated that addition of methionine and threonine to a protein-free diet reduced urinary N excretion more than addition of methionine alone.…”

Section: Effect Of the Length Of The Experimental Period On The Bvmentioning

confidence: 97%

Nutritive efficiencies of lactalbumin and wheat gluten at very low levels of intake in adult rats.

Miyatani

Kishi

Takahashi

et al. 1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe nutritive values of proteins in relation to their intake levels were evaluated by feeding adult male rats weighing 250g diets containing 0%, 0.39%, 0.78%, 1.56 %, 2.34%, 3.90%, 7.79% and 15.58 lactalbumin or wheat gluten for three weeks. The biological values (BV) of both proteins were high at low levels of protein intake but decreased with increase in protein intake. The BY of wheat gluten was estimated to be about 100 at a level of intake of 1.56% but only 25 at a level of 15.58%. Similarly, the BY of lactalbumin decreased with increase in the protein level, being 67 at a level of 7.79%. The BVs of both proteins at low levels of dietary protein (below 2.34% of lactalbumin or 0.78% of wheat gluten) were apparently more than 100 because urinary N excretion was less than endogenous N. The BVs also decreased with time during the three-week test period. It is concluded that the BY of a protein is not a fixed value but varies with the experimental conditions especially with changes in the amount of intake, and that differences in the qualities of various proteins cannot be compared quantitatively at a single level of protein. The results were briefly discussed in relation to protein require ments.

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Some Effects of Methionine on the Utilization of Nitrogen in the Adult Dog

Cited by 63 publications

References 7 publications

Alleviation of body weight loss by dietary methionine is independent of insulin‐like growth factor‐I in protein‐starved young chickens

Alleviation of body weight loss by dietary methionine is independent of insulin‐like growth factor‐I in protein‐starved young chickens

Comparative nutrition and metabolism: Explication of open questions with emphasis on protein and amino acids

Nutritive efficiencies of lactalbumin and wheat gluten at very low levels of intake in adult rats.

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