SOME EFFECTS OF<i>IN VIVO</i>ADMINISTERED ESTROGENS ON GLUCOSE METABOLISM AND ADRENAL CORTICAL SECRETION<i>IN VITRO</i>

McKerns, Kenneth W.; Coulomb, B.S.; Kaleita, E.; Renzo, E.C. De

doi:10.1210/endo-63-6-709

Cited by 49 publications

(9 citation statements)

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“…Estrogens increase circulating glucocorticoid tilers [8] which increase hepatic glycogen [II], However, glucocorticoids antagonize in sulin-mediated glucose uptake into skeletal muscle [11], whereas estradiol increased the glycogen content of this tissue in the present study. Furthermore, estrogens synergize the action of insulin on skeletal muscle [15,21] and increase glucose uptake in uterus by acti vation of a specific transport system [19. 25].…”

Section: Discussionmentioning

confidence: 99%

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis Glycogen Formation and Gluconeogenesis

Ahmed-Sorour

Bailey²

1981

Ann Nutr Metab

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The effect of ovarian hormones on in vivo gluconeogenesis and glycogen deposition in liver, uterus, skeletal and cardiac muscle was studied. Ovariectomized adult female mice were treated with replacement doses of estradiol, progesterone, both hormones combined, or vehicle only for 15 weeks. Compared with intact control mice, ovariectomy increased gluconeogenesis and reduced the glycogen content of all tissues examined. Treatment with estradiol and progesterone, individually and in combination, increased tissue glycogen deposition. Estradiol alone consistently produced the greatest effect, except on hepatic glycogen, which was maximally increased by the combined estradiol-progesterone regimen. Estradiol markedly reduced gluconeogenesis, and this effect was antagonized by progesterone. The results indicate that the lower plasma glucose concentrations produced by ovarian steroids result in part from reduced glucose neoformation and greater storage of glycogen in liver and muscle tissues.

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Section: Discussionmentioning

confidence: 99%

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis Glycogen Formation and Gluconeogenesis

Ahmed-Sorour

Bailey²

1981

Ann Nutr Metab

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“…However, these effects would impede rather than enhance the hypo glycaemic action of insulin [Ensinck and Williams. 1972], Conversely, pro gesterone reduces plasma growth hormone [Bhatia et al, 1972], and oestro gens have been reported to synergize the action of insulin on adipose tissue and skeletal muscle [McKerns et al, 1958;Gilmour and McKerns. 1966;Shamoon and Felig.…”

Section: Discussionmentioning

confidence: 99%

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis

Ahmed-Sorour

Bailey²

1980

Horm Res

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This study examines the effects of ovarian hormones on the glycaemic actions of insulin, glucagon and epinephrine. Ovariectomized adult female mice were treated with replacement doses of oestradiol, progesterone, both hormones combined or vehicle only for 15 weeks. Compared with intact control mice, ovariectomy did not significantly alter insulin-induced hypoglycaemia. However, treatment with oestradiol or progesterone alone, but not in combination, increased the hypoglycaemic action of insulin. The hyperglycaemic effect of glucagon and epinephrine was increased by ovariectomy and reduced by the ovarian hormone treatments. The results indicate that oestradiol and progesterone individually synergize the hypoglycaemic action of insulin, but mutually antagonize each other in this respect. Oestradiol and progesterone, individually and in combination, appear to suppress the glycogenolytic action of glucagon and epinephrine.

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“…Estradiol benzoate induced by estradiol, as demonstrated in vitro on diaphragms taken from pre-treated rats [27], or to a decrease in hepatic glnconeogenesis, as reported in rats treated by estradiol by Mature and KMkhoff [28].…”

Section: Discussionmentioning

confidence: 92%

Sex related diurnal variations in venous blood glucose and plasma insulin levels effects of estrogens in men

et al. 1974

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Summary. Significant sex differences were observed in 24 young lean men and women submitted to two mixed isocMorie meals (880 KcM; protein 40 g; carbohydrate 90 g; fat 40 g;) at 8.15 AM and 12.45 PM. After an overnight fast venous blood glucose levels were lower in women than in men. Plasma insulin responses were lower after the afternoon meal than after the morning one in men bu~ not in women. Thus women did not present the well known cycle of insulin secretion described in men. Estradiol benzoate, 10 mg per day given intra-muscularly for eight days in six men who served as their own control, lowered fasting venous blood glucose levels and enhanced post prandial plasma insulin levels after the morning and the afternoon meal as well. It is suggested that the sex related differences in venous blood glucose and plasma insulin patterns may be due in part to estrogens.Key words: Blood glucose, plasma insulin, meals, diurnal patterns, estrogens.Diurnal and circadian changes in blood glucose and plasma insulin levels have been described in man by several authors [1--13]. The insulin secretion induced by oral glucose [1,6,7, 11,13], tolbutamide [2,13] or isoealorie meals [3,5] was more pronounced in the morning than in the afternoon. Blood glucose levels were lower in the morning than in the afternoon in response to various stimuli [1, 2, 6, 7, 9--13], but not after meals [3].After 3 and 4 days of total fast, plasma insulin levels were higher in the morning than in the afternoon in normal young men [1r These studies were done mainly or only in men.In male rats a daily rhythm of plasma glucose and insulin levels [15] and a diurnal cycle in the pancreatic beta and alpha 2 cells nuclear size [16] were described.The possibility that the circadian variations observed in blood glucose and plasma insulin levels might be sex-related has not been studied until now. However sex-related differences have been observed in substrate and hormone studies. Women responded more than men to several stimuli of Growth Hormone (GH) secretion [17]. Merimee and Fineberg have recently shown [18] that in fasting women venous blood glucose levels decrease more than in fasting men, without significant differences in plasma insulin levels. In rats blood glucose levels were higher fasting in females than in males [19]. Estrogen administration enhanced GI-I secretion in men [17,20], insulin secretion in the rat [21--23] and lowered the post absorptive blood glucose levels in men [17].The aim of this study was to compare the diurnal changes of venous glucose and plasma insulin values in men and women submitted, after an overnight fast, to two identical meals at 8.15 A?r and 12.45 PM. Some men were reinvestigated after parenterM estradiol benzoate administration.

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SOME EFFECTS OFIN VIVOADMINISTERED ESTROGENS ON GLUCOSE METABOLISM AND ADRENAL CORTICAL SECRETIONIN VITRO

Cited by 49 publications

References 0 publications

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis Glycogen Formation and Gluconeogenesis

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis Glycogen Formation and Gluconeogenesis

Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis

Sex related diurnal variations in venous blood glucose and plasma insulin levels effects of estrogens in men

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