Some Effects of Dmso on Human Skin in Vivo

Sulzberger, Marion B.; Cortese, Thomas A.; Fishman, Leonard; Wiley, Hugh S.; Peyakovich, Paul S.

doi:10.1111/j.1749-6632.1967.tb34908.x

Cited by 50 publications

(15 citation statements)

References 5 publications

(1 reference statement)

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“…It also displays skin-related antinociception in topical preparations in conjuction with morphine or lidocaine (Kumar et al 2011;Kolesnikov et al 2000), which goes beyond that presented by either archetype analgesic agent. These antinociceptive effects might have to do with DMSO-induced dampening of peripheral C-fiber activity (Shealy 1966) or with its easy penetration into the stratum corneum when applied to the skin surface (Sulzberger et al 1967), which makes DMSO a carrier of the accompanying analgesic compunds into deeper skin layers. DMSO applied alone, however, seems to lose its analgesic power (Kolesnikov et al 2000).…”

Section: Resultsmentioning

confidence: 99%

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Takeda

Pokorski

Okada

2016

Advances in Experimental Medicine and Biology

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Dimethyl sulfoxide (DMSO) is commonly used as a solvent for hydrophobic substances, but the compound's innate bioactivity is an area of limited understanding. In this investigation we seek to determine the analgesic potential of DMSO. We addressed the issue by assessing the perception of thermal pain stimulus, using a 55 °C hotplate design, in conscious mice. The latency of withdrawal behaviors over a range of incremental accumulative intraperitoneal DMSO doses (0.5-15.5 g/kg) in the same mouse was taken as a measure of thermal endurance. The findings were that the latency, on average, amounted to 15-30 s and it differed inappreciably between the sequential DMSO conditions. Nor was it different from the pre-DMSO control conditions. Thus, DMSO did not influence the cutaneous thermal pain perception. The findings do not lend support to those literature reports that point to the plausible antinociceptive potential of DMSO as one of a plethora of its innate bioactivities. However, the findings concern the mouse's footpad nociceptors which have specific morphology and stimulus transduction pathways, which cannot exclude DMSO's antinociceptive influence on other types of pain or in other types of skin. Complex and as yet unresolved neural mechanisms of perception of cutaneous noxious heat stimulus should be further explored with alternative experimental designs.

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Section: Resultsmentioning

confidence: 99%

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Takeda

Pokorski

Okada

2016

Advances in Experimental Medicine and Biology

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“…It forms microcavities within the lipid bilayers and increases drug partitioning across the skin [35,36]. DMSO has a long clinical history of topical use to treat allergy, and inflammation, especially in combination with non-steroidal anti-inflammatory drugs; the applied concentration varies largely reaching 90 or 100% concentration [37,38,39,40,41,42]. …”

Section: Resultsmentioning

confidence: 99%

Could Chemical Enhancement of Gold Nanoparticle Penetration Be Extrapolated from Established Approaches for Drug Permeation?

El-Khordagui

Schneider

2012

Skin Pharmacol Physiol

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Background and Aim: Investigations on chemical enhancement of skin penetration of gold nanoparticles are considered crucial to have a deeper insight into the main barrier of particle penetration. Methods: In this study, penetration of gold nanoparticles in the presence of several chemical enhancers – urea, sodium lauryl sulphate, polysorbate 80 and dimethyl sulfoxide (DMSO) – through human skin was studied. Results: Among the tested chemical enhancers, DMSO could induce the penetration of hydrophilic (citrate-stabilized) gold colloid of no intrinsic penetration ability in a concentration-dependent manner. Pretreatment of the skin with DMSO however reduced the penetration of hydrophobic (cetrimide-coated) gold nanoparticles as a result of aggregation in the top layers of the stratum corneum limiting penetration into the deeper skin layers. In addition, nanoparticles-vehicle interaction and the stability of the nanoparticles in the applied vehicle were found important determinants of skin penetration. Conclusion: Our results demonstrate that the already established approaches for chemical permeation enhancement of drug molecules and their postulated mechanisms could be used as preliminary guidelines for enhancing the penetration of nanoparticles. At this size range of 15 nm, intercellular lipids provide the main barrier to particle penetration through the stratum corneum.

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“…As thorough chlorophyll extraction has been reported for DMSO as solvent in previous studies (Barnes et al, 1992;Castle et al, 2011) and a good reproducibility of the results has been shown for biocrusts in this study (Table S3) and for leaf fragments by Tait and Hik (2003), we believe that this variability reflects the actual variability in chlorophyll contents between samples. In contrast to the extraction efficiency, ethanol has the advantage of being non-toxic (Lan et al, 2011), whereas DMSO has a potential to carry dissolved substances into the body through the skin (Horita and Weber, 1964;Sulzberger et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Revisiting chlorophyll extraction methods in biological soil crusts – methodology for determination of chlorophyll a and chlorophyll a + b as compared to previous methods

et al. 2018

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Abstract. Chlorophyll concentrations of biological soil crust (biocrust) samples are commonly determined to quantify the relevance of photosynthetically active organisms within these surface soil communities. Whereas chlorophyll extraction methods for freshwater algae and leaf tissues of vascular plants are well established, there is still some uncertainty regarding the optimal extraction method for biocrusts, where organism composition is highly variable and samples comprise major amounts of soil. In this study we analyzed the efficiency of two different chlorophyll extraction solvents, the effect of grinding the soil samples prior to the extraction procedure, and the impact of shaking as an intermediate step during extraction. The analyses were conducted on four different types of biocrusts. Our results show that for all biocrust types chlorophyll contents obtained with ethanol were significantly lower than those obtained using dimethyl sulfoxide (DMSO) as a solvent. Grinding of biocrust samples prior to analysis caused a highly significant decrease in chlorophyll content for green algal lichen- and cyanolichen-dominated biocrusts, and a tendency towards lower values for moss- and algae-dominated biocrusts. Shaking of the samples after each extraction step had a significant positive effect on the chlorophyll content of green algal lichen- and cyanolichen-dominated biocrusts. Based on our results we confirm a DMSO-based chlorophyll extraction method without grinding pretreatment and suggest the addition of an intermediate shaking step for complete chlorophyll extraction (see Supplement S6 for detailed manual). Determination of a universal chlorophyll extraction method for biocrusts is essential for the inter-comparability of publications conducted across all continents.

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Some Effects of Dmso on Human Skin in Vivo

Cited by 50 publications

References 5 publications

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Could Chemical Enhancement of Gold Nanoparticle Penetration Be Extrapolated from Established Approaches for Drug Permeation?

Revisiting chlorophyll extraction methods in biological soil crusts – methodology for determination of chlorophyll <i>a</i> and chlorophyll <i>a</i> + <i>b</i> as compared to previous methods

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Some Effects of Dmso on Human Skin in Vivo

Cited by 50 publications

References 5 publications

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Could Chemical Enhancement of Gold Nanoparticle Penetration Be Extrapolated from Established Approaches for Drug Permeation?

Revisiting chlorophyll extraction methods in biological soil crusts – methodology for determination of chlorophyll &lt;i&gt;a&lt;/i&gt; and chlorophyll &lt;i&gt;a&lt;/i&gt; + &lt;i&gt;b&lt;/i&gt; as compared to previous methods

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Revisiting chlorophyll extraction methods in biological soil crusts – methodology for determination of chlorophyll <i>a</i> and chlorophyll <i>a</i> + <i>b</i> as compared to previous methods