Some Discharge Characteristics of Single Neurons in the Inferior Colliculus of the Cat. I. Tonotopical Organization, Relation of Spike-Counts to Tone Intensity, and Firing Patterns of Single Elements

Rose, Jerzy E.; Greenwood, Donald D.; Goldberg, Jay M.; Hind, Joseph E.

doi:10.1152/jn.1963.26.2.294

Cited by 343 publications

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“…As the electrode was advanced, BFs first decreased, then increased. This frequency reversal occurred ϳ1-2 mm below the surface and signified transition from the dorsal cortex or external nucleus into the central nucleus (Rose et al, 1963;Merzenich and Reid, 1974;Aitkin et al, 1975). Neurons in the dorsal cortex or external nucleus were often tuned poorly, adapted rapidly, or exhibited marked offset responses; neurons within the ICC were usually sharply tuned with short latencies (Merzenich and Reid, 1974;Aitkin et al, 1975).…”

Section: Methodsmentioning

confidence: 99%

Limited Segregation of Different Types of Sound Localization Information among Classes of Units in the Inferior Colliculus

Chase¹,

Young²

2005

J. Neurosci.

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Section: Methodsmentioning

confidence: 99%

Limited Segregation of Different Types of Sound Localization Information among Classes of Units in the Inferior Colliculus

Chase¹,

Young²

2005

J. Neurosci.

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“…Early studies found that the spike rates of many cells did not monotonically increase as the intensity of pure tone stimulus increased, indicating the effects of side-band inhibition [Rose et al, 1963]. Recent studies have identified 4 classes of tuning curves found in the ICC of awake mice using single and two-tone stimulus protocols to facilitate the measurement of inhibitory response areas.…”

Section: The Inferior Colliculusmentioning

confidence: 99%

Efficient Encoding Of Vocalizations In The Auditory Midbrain

Holmstrom¹

2000

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An important question in sensory neuroscience is what coding strategies and mechanisms are used by the brain to detect and discriminate among behaviorally relevant stimuli. To address the noisy response properties of individual neurons, sensory systems often utilize broadly tuned neurons with overlapping receptive fields at the system's periphery, resulting in homogeneous responses among neighboring populations of neurons. It has been hypothesized that progressive response heterogeneity in ascending sensory pathways is evidence of an efficient encoding strategy that minimizes the redundancy of the peripheral neural code and maximizes information throughput for higher level processing. This hypothesis has been partly supported by the documentation of neural heterogeneity in various cortical structures.This dissertation examines whether selective and sensitive responses to behaviorally relevant stimuli contribute to a heterogeneous and efficient encoding in the auditory midbrain. Prior to this study, no compelling experimental framework ex- My parents, for their support throughout all of my education. Not only did they instill in me a confidence that I could take on any educational challenge, but they supported me when I chose not to take these challenges on. I'm sure they worried about me when I dropped out of college in 1993, but their trust in my own decision making process was a better lesson for me to learn at the time.My sister, for teaching me how to fight for the important things in life.My entire committee, for challenging me to push my limits (which I discovered on many occasions). I have leaned on each and every one of them at different times through this process. I am very grateful to have had access to a group so diverse in their specialties, yet so consistent in their kindness, approachability, depth of knowledge, and eagerness to share this knowledge. I couldn't have done this without a single one of them.Lonneke Eeuwes, for all of the long hours she spent collecting data for our experiii iments and carefully reading through my manuscripts.Sunghan Kim, for working with me through the technical details of our state space frequency tracking methods. My research was made possible by your work.Roberto Santiago, for taking me under his wing as a fresh graduate student and imbuing me with a sense of adventure about research. He taught me that the challenges inherent in science are not a chore, but a privilege to be relished.John Vasallo, for setting time aside for our weekly musical catharsis and for being flexible with respect to my constantly shifting schedule. He almost single handedly ensured that playing music will continue to be an important part of my life.Todd Haynes, for his roving intellect and dedication to the creative process. I can only hope that I can tap into a similar wellspring of enthusiasm, kindness, and vision.

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“…Subcortical FRAs, up to the inferior colliculus (IC), are mostly level intolerant in that FRAs become wider at higher sound levels (Rose et al, 1963;Popper and Fay, 1992;Davis, 2005), with a few exceptions. Level-tuned units have been reported in the dorsal cochlear nucleus (Spirou and Young, 1991) and the IC (Yang et al, 1992;Ramachandran et al, 1999;LeBeau et al, 2001), but their best levels (BLs) (sound level eliciting maximal response) are confined to a narrow range of near-threshold values.…”

Section: Introductionmentioning

confidence: 99%

Level Invariant Representation of Sounds by Populations of Neurons in Primary Auditory Cortex

Sadagopan

Wang²

2008

J. Neurosci.

129

168

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A fundamental feature of auditory perception is the constancy of sound recognition over a large range of intensities. Although this invariance has been described in behavioral studies, the underlying neural mechanism is essentially unknown. Here we show a putative level-invariant representation of sounds by populations of neurons in primary auditory cortex (A1) that may provide a neural basis for the behavioral observations. Previous studies reported that pure-tone frequency tuning of most A1 neurons widens with increasing sound level. In sharp contrast, we found that a large proportion of neurons in A1 of awake marmosets were narrowly and separably tuned to both frequency and sound level. Tuning characteristics and firing rates of the neural population were preserved across all tested sound levels. These response properties lead to a level-invariant representation of sounds over the population of A1 neurons. Such a representation is an important step for robust feature recognition in natural environments.

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Some Discharge Characteristics of Single Neurons in the Inferior Colliculus of the Cat. I. Tonotopical Organization, Relation of Spike-Counts to Tone Intensity, and Firing Patterns of Single Elements

Cited by 343 publications

References 0 publications

Limited Segregation of Different Types of Sound Localization Information among Classes of Units in the Inferior Colliculus

Limited Segregation of Different Types of Sound Localization Information among Classes of Units in the Inferior Colliculus

Efficient Encoding Of Vocalizations In The Auditory Midbrain

Level Invariant Representation of Sounds by Populations of Neurons in Primary Auditory Cortex

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