Some derivatives of rhodanine as analytical reagents

Stephen, W.I.; Townshend, Alan

doi:10.1016/s0003-2670(01)84888-1

Cited by 31 publications

(13 citation statements)

References 22 publications

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“…[4] Azo compounds in perspective of rhodanine were mixed as potential helpful courses of action and can moreover be used as consistent reagents and in analytical chemistry. [5,6] The ligands with potential sulfur, oxygen and nitrogen donors, for example, rhodanine and its derivatives are entirely intriguing which have gained special attention in the most recent decade, not just due to the structural chemistry and their importance in medical chemistry, additionally in light these materials are used as a drugs and they are reported to possess a wide variety of antimicrobial activities against bacteria and fungi. They are additionally turned into a helpful model for bioinorganic forms, which has numerous biochemical and pharmacological application and also used in antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal properties, Calf thymus DNA binding and quantum chemical studies of M(II) complexes

Morgan¹,

Diab

El‐Sonbati

2018

Applied Organom Chemis

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A new series of transition metal complexes of Cu(II), Co(II), Ni(II), Mn(II) and Cd(II) were prepared from the ligand of 5-(4-benzenesulfonic acid azo)-2thioxo-4-thiazolidinone (H 2 L). The M(II) complexes were structurally elucidated by elemental analysis, infrared spectra, spectral studies, thermal analysis, magnetic measurements and X-ray diffraction analysis. Elemental analysis and IR result suggested the ligand was bonded to the metal ions in monobasic/neutral bidentate through the nitrogen atom of the hydrazone group and oxygen atom of carbonyl group. The bond length, bond angle, HOMO, LUMO and quantum chemical parameters were calculated to confirm the geometry of the ligand and the M(II) complexes. In vitro antimicrobial behavior of ligand (H 2 L) and its M(II) complexes (1-5) was screened with targeted bacterial and fungal strains. Spectroscopic (UV-vis) technique was employed in order to study the binding mode and binding strength of the ligand (H 2 L) and its M(II) complexes to Calf thymus DNA (CT-DNA). Intercalation is the most possible mode of interaction of the ligand (H 2 L) and its M(II) complexes with CT-DNA and the determined binding constants. Molecular docking was used to predict the binding between the starts (4-aminobenzenesulfonic acid (start 1) and 2-thioxo-4-thiazolidinone (start 2)) and tautomers (A-C) of ligand (H 2 L) with the receptors of prostate cancer mutant (PDB code: 2Q7K) and breast cancer mutant (PDB code: 3HB5).

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal properties, Calf thymus DNA binding and quantum chemical studies of M(II) complexes

Morgan¹,

Diab

El‐Sonbati

2018

Applied Organom Chemis

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“…The average number of the reagent molecules attached per metal ion, n , and free ligand exponent, pL, can be calculated using Eqs. (2) and (3):…”

Section: Potentiometric Studiesmentioning

confidence: 99%

“…Azo compounds based on rhodanine were synthesized as potential medicinal preparations [1] and can also be used as analytical reagents [2]. It is known that rhodanine plays an important role in biological reactions [3,4].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic, potentiometric and thermodynamic studies of azo rhodanines and their metal complexes

El‐Sonbati

El-Bindary

El-Meksoud

et al. 2014

Journal of Molecular Liquids

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“…[10,[12][13][14][15] Chemical properties of rhodanine and its derivatives are of interest due to their coordination capacity and their use as metal extracting agents and as analytical reagents. [16,17] A large number of allylazo-and/or hydrazorhodanine derivatives have been prepared and characterized using magnetic and spectral studies. [7,8,10] The existing literature on the coordination chemistry of such classes of ligands is scarce.…”

Section: Introductionmentioning

confidence: 99%

Polymer complexes. LXXII. Spectroscopic studies, thermodynamics, DNA binding and biological activity of polymer complexes

El‐Sonbati

Diab

Serag

2019

Applied Organom Chemis

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A novel series of copper polymer complexes (1–4) were synthesized and characterized using various spectroscopic techniques. Spectra of all polymer complexes a tetragonal distorted geometry for the Cu(II) ion. The electronic spectra, magnetic moments and electron spin resonance results indicate tetragonal distortion geometry for the Cu(II) polymer complexes. The effects of various solvents on absorption spectra of the ligand are discussed. A prediction of the interaction of the ligand against anti‐cancer receptors was carried out using AutoDock server. The affinity of the compounds to calf thymus DNA was determined through UV–visible DNA binding titration, and intrinsic binding constant (Kb) was found to be 4.16 × 103, 3.10 × 105, 3.18 × 104 and 2.91 × 105 for polymer complexes 1–4, respectively. The antimicrobial activity of the polymer complexes against bacterial species (Bacillus cereus, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Enterococcus faecalis and Pseudomonas aeruginosa) and fungal species (Aspergillus niger, Fusarium oxysporum and Candida albicans) was investigated.

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Some derivatives of rhodanine as analytical reagents

Cited by 31 publications

References 22 publications

Synthesis, spectroscopic, thermal properties, Calf thymus DNA binding and quantum chemical studies of M(II) complexes

Synthesis, spectroscopic, thermal properties, Calf thymus DNA binding and quantum chemical studies of M(II) complexes

Spectroscopic, potentiometric and thermodynamic studies of azo rhodanines and their metal complexes

Polymer complexes. LXXII. Spectroscopic studies, thermodynamics, DNA binding and biological activity of polymer complexes

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