Some Cytogenetic Aspects of Intersexuality in the Bovine

Kieffer, Michel; Am, Sorensen

doi:10.2527/jas1971.3261219x

Cited by 5 publications

(1 citation statement)

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“…However, re-examining an old article [Kiefer and Sorensen, 1971], it is possible to notice that 1 of these 3 animals described has an XX karyotype and testis plus ovotestis development (right and left gonad, respectively). It cannot be excluded that this case was caused by an SRY translocation into X (as is the case of 80% of human XX sex-reversal cases), but this represents the only XX sex-reversal case to be reported in cattle.…”

Section: Gonadal Differentiation Abnormalitiesmentioning

confidence: 99%

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Villagómez

Parma

Radi

et al. 2009

Cytogenet Genome Res

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The association of abnormal chromosome constitutions and disorders of sex development in domestic animals has been recorded since the beginnings of conventional cytogenetic analysis. Deviated karyotypes consisting of abnormal sex chromosome sets (e.g. aneuploidy) and/or the coexistence of cells with different sex chromosome constitutions (e.g. mosaicism or chimerism) in an individual seem to be the main causes of anomalies of sex determination and sex differentiation. Molecular cytogenetics and genetics have increased our understanding of these pathologies, where human and mouse models have provided a substantial amount of knowledge, leading to the discovery of a number of genes implicated in mammalian sex determination and differentiation. Additionally, other genes, which appeared to be involved in ovary differentiation, have been found by investigations in domestic species such as the goat. In this paper, we present an overview of the biology of mammalian sex development as a scientific background for better understanding the body of knowledge of the clinical cytogenetics of disorders of sex development in domestic animals. An attempt to summarize of what has been described in that particular subject of veterinary medicine for each of the main mammalian domestic species is presented here.

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Section: Gonadal Differentiation Abnormalitiesmentioning

confidence: 99%