Some clinical observations and impressions on asyndrome of tremors in infants from India

Kaul, K. K.; Prasan, N. G.; Chowdhry, Raj M.

doi:10.1016/s0022-3476(63)80199-7

Cited by 25 publications

(27 citation statements)

References 3 publications

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“…The disorder has been reported under various other names, namely, nutritional dystrophy and anemia,[ 1 ] infantile meningoencephalitic syndrome,[ 7 ] vitamin B 12 deficiency in Indian infants,[ 8 ] megaloblastic anemia of infancy and vitamin B 12 ,[ 9 ] syndrome of tremors in infants,[ 10 ] syndrome of tremors, mental regression and anemia,[ 11 ] and tremors, mental and physical retardation, light colored hairs and anemia in malnourished children. [ 12 ] Since, the tremors are the dominant recognizable feature of this disorder and affect children below 2 years of age, the term infantile tremor syndrome or ITS gained popularity.…”

Section: Literature Searchmentioning

confidence: 99%

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Infantile tremor syndrome: A review and critical appraisal of its etiology

Goraya

Kaur

2016

J Pediatr Neurosci

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Infantile tremor syndrome (ITS) is defined by the tetrad of pallor, developmental delay/regression, skin pigmentation, and brown scanty scalp hair. Involuntary movements in the form of tremors supervene in the natural course of the illness in a significant number of cases. The disorder occurs in exclusively breast-fed infants of vegetarian mothers belonging to economically deprived sections of society. Most of the children eventually recover but are frequently left with long-term cognitive and language neurodeficits. ITS continues to be seen in clinical practice, but there has been no consensus on its causation. Last comprehensive review was published in 1987 describing the ITS as a syndrome of unknown or multiple etiologies. Several important papers have been published since then. This review attempts to provide comprehensive and up-to-date information on the subject incorporating recently published studies. In the end, the issue of etiology is objectively re-examined in the light of available evidence some of which has been published in recent years.

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Section: Literature Searchmentioning

confidence: 99%

“…[ 8 ] Maternal health in many studies has been stated to be poor with multiple nutritional deficiencies,[ 6 8 12 14 16 ] while others have provided no information on maternal diet and nutritional health. [ 7 10 11 13 17 ]…”

Section: Epidemiologymentioning

confidence: 99%

Infantile tremor syndrome: A review and critical appraisal of its etiology

Goraya

Kaur

2016

J Pediatr Neurosci

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“…1,2,5,6 The effect of a Cbl deficiency on the growing brain is also well recognised and children with MA have been reported to have developmental retardation/regression, hypotonia, tremors and other abnormal movements. [7][8][9][10] During a recent study of infants and children with MA, we observed tremors after commencement of B 12 therapy. During follow-up, some patients developed thrombocytosis, which also forms part of this communication.…”

Section: Introductionmentioning

confidence: 96%

Tremors and thrombocytosis during treatment of megaloblastic anaemia

Chandra¹,

Jain²,

Narayan

et al. 2006

Annals of Tropical Paediatrics

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In developing countries, a deficiency of cobalamine and folate contributes significantly to megaloblastic anaemia. Neurological observations in infants and young children with megaloblastic anaemia have included hypotonia, developmental regression, tremors and other abnormal movements. Following therapy with vitamin B12, coarse tremors occurred in six of 51 patients (12%) with megaloblastic anaemia. The tremors, which were noticed initially in the hands and feet, gradually became generalised and disappeared during sleep. They subsided within 5-11 days. Thirteen of 25 (52%) patients developed thrombocytosis between day 3 and week 5 of follow-up. In one child, the platelet count increased to >1300 x 10(9)/L. The importance of recognising these clinical findings during treatment of megaloblastic anaemia is emphasised.

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“…suggested that Vitamin B12 deficiency might be an important factor in the biochemical process resulting in ITS. [ 3 ] Sachdev et al . have reported macrocytic anemia in 58 out of 80 cases of ITS.…”

Section: Introductionmentioning

confidence: 99%

Infantile tremor syndrome: Role of Vitamin B12 revisited

et al. 2016

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Objective:To study the role of Vitamin B12 as an etiological factor in patients of infantile tremor syndrome (ITS).Methods:Twelve consecutive admissions of children diagnosed clinically as ITS were assessed. Assessment was done using a predefined pro forma to document patient demographic factors, general examination, systemic examination as well as relevant hematological and biochemical investigations.Results:Out of the 12 cases of ITS, 6 were males and 6 were females. Two cases had serum B12 levels below reference values, five had levels in low normal range, and remaining five had normal values.Conclusions:Role of Vitamin B12 deficiency as an etiological factor in the patients of ITS is inconclusive.

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Some clinical observations and impressions on asyndrome of tremors in infants from India

Cited by 25 publications

References 3 publications

Infantile tremor syndrome: A review and critical appraisal of its etiology

Infantile tremor syndrome: A review and critical appraisal of its etiology

Tremors and thrombocytosis during treatment of megaloblastic anaemia

Infantile tremor syndrome: Role of Vitamin B12 revisited

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