Some Clinical, Biochemical and Genetic Observations on Hemoglobin C

Observations on the Inheritance of Sickle-Cell Hemoglobin and Hemoglobin C1

“…The clinical features of the cases of sickle-cell-hemoglobin C disease in this study are similar to those previously reported (2)(3)(4)(5)(6). The case histories are presented primarily to provide a documentary basis for the genetic considerations.…”

“…However, by studying the offspring of marriages of sickle-cell-hemoglobin C disease x normal, some conclusions as to independence vs. allelism or close linkage may be reached. The present report includes seven families in which both sicklecell hemoglobin and hemoglobin C have been found, in addition to three similar families which were reported previously (4). The number of observations is now large enough to permit some conclusions about the relationships of the genes for C and S hemoglobins.…”

“…The data from this and previous study (4) are summarized in Table I. Photographs of the filter paper electrophoresis study of one family in each of groups I and II, and of each family study in groups III and IV are shown in Figure 1.…”

“…The (Figure 2, group III, b). This family consisting of a father with sickle-cell-hemoglobin C disease has been reported previously (4). The hemoglobin of his wife was normal; one son had sickle-cell trait, and the other hemoglobin C trait.…”

“…The presence of hemoglobin C appears to depend upon a single gene which is transmitted as a simple Mendelian dominant (2)(3)(4). The presence of sickle-cell hemoglobin is similarly determined by a single autosomal dominant gene.…”