Some Characteristics of Nocturnal Penile Tumescence in Elderly Males

Karacan, Ismet; Hursch, Carolyn J.; Williams, Robert L.

doi:10.1093/geronj/27.1.39

Cited by 76 publications

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“…The vast majority of erectile events was coupled to REM episodes, where the latency between the beginning of erections and REM episodes showed a large variability, which is in accordance with former studies [14,15]. The more detailed evaluation of the temporal relationship by means of a correlation and regression analysis revealed a highly significant decrease of the latency in the course of the night, i.e.…”

Section: Discussionsupporting

confidence: 90%

Temporal Relationship between Nocturnal Erections and Rapid Eye Movement Episodes in Healthy Men

et al. 2003

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The exact temporal relationship between spontaneous nocturnal erections and rapid eye movement (REM) sleep was studied in healthy men with the aim of creating a basis for a more sophisticated analysis of nocturnal erection measurements in physiological research and clinical applications. The vast majority of erectile events was coupled to REM episodes, where the latency between the beginning of erections and REM episodes showed a large variability. Moreover, a correlation analysis revealed a highly significant decrease of the latency over the course of the night. The time variant properties of the coupling between erections and REM sleep point to more complex dynamics of the central control of erections with regard to sleep regulation, indicating that REM sleep and REM-related erections are not completely interdependent. Beside the possibility of obtaining further insight into the physiological mechanisms underlying erectile function, the consideration of dynamic aspects in the assessment of nocturnal erection measurements might have potential clinical implications regarding both the diagnosis and the evaluation of therapies for erectile dysfunction.

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Section: Discussionsupporting

confidence: 90%

Temporal Relationship between Nocturnal Erections and Rapid Eye Movement Episodes in Healthy Men

et al. 2003

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“…Karacan established that the duration of the complete penile tumescence expressed as percentage of total sleep is 32.1% in young males, 31.6% in middle-aged males and 20.6% in elderly males. 11 In our population with normal rigidity measurements (mean age 48 y), such duration was 33% and it did not change signi®cantly with the medication. Instead, in our population with abnormal rigidity measurements, the complete penile tumescence duration was 17.9% increasing signi®cantly to 23.4% with the use of sildena®l (mean age 45 y).…”

Section: Discussionmentioning

confidence: 52%

Sildenafil improves nocturnal penile erections in organic impotence

et al. 2001

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We studied the effects of sildena®l on nocturnal penile erections. We prospectively evaluated 36 patients with organic or psychogenic impotence and 5 normal, potent men. All patients completed 3 sessions of consecutive nights using the RigiScan Plus device. The ®rst two nights the patients were asked to take placebo before the session and to take 50 mg of sildena®l before the third session. In the organic impotence group the use of sildena®l induced a signi®cant improvement in time of rigidity 60 ± 100%, rigidity and tumescence activity unit values and rigidity and tumescence activity unit values per hour in the tip and base. In the psychogenic impotence group it caused signi®cant improvement only in rigidity activity unit per hour in the tip. In the potent men, changes were statistically insigni®cant. Sildena®l improves nocturnal penile erectile activity in organic impotence. Our study shows that phosphodiesterase inhibitors can improve penile erections not induced by sexual stimulation.

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“…Nocturnal erections are usually present during a quarter of sleep time (associated with rapid-eye movement sleep) [17] and therefore represent a significant proportion of total erectile tissue activity, but are reduced in patients at risk of erectile disorders [18]. During an erection, blood flow increases 25-60 times [19] and the partial oxygen pressure in cavernous blood increases by 250-500% [2].…”

Section: Discussionmentioning

confidence: 99%

Long‐term treatment of erectile dysfunction with a phosphodiesterase‐5 inhibitor and dose optimization based on nocturnal penile tumescence

et al. 2008

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Study Type -Therapy (RCT) Level of Evidence 1b OBJECTIVETo test the hypothesis that a variable dosage of the oral phosphodiesterase type 5 (PDE5) inhibitor sildenafil (25, 50, 100 mg) or vardenafil (5, 10, 25 mg) determined according to results obtained from nocturnal penile tumescence and rigidity (NPTR, RigiScan), given nightly for 1 year, can improve spontaneous erectile function (EF) in men with mild-to-moderate arteriogenic erectile dysfunction (ED); this regimen was compared with a fixed daily dosage of sildenafil 25 mg or vardenafil 5 mg. PATIENTS AND METHODSIn a prospective open-label, parallel-group trial 154 men with ED were randomized either to fixed low-dose sildenafil 25 mg or vardenafil 5 mg (group 1) or to the lowest erectile dosage of sildenafil (25, 50 or 100 mg) or vardenafil (5, 10 or 20 mg) (group 2) provoking an erectile event as measured by NPTR nightly for 1 year. The EF domain of the International Index of Erectile Function (IIEF) was assessed before and 1 year after the beginning of treatment, and at 4 weeks after ending treatment. RESULTSAfter 1 year, 27 of 63 (64%) evaluable men in group 1 had an EF domain score in the normal range, vs 46 of 61 (75%) men in group 2. After the subsequent 4-week wash-out phase, both groups continued to have improved EF domain scores; 22 of 63 (35%) men in group 1 still had a score in the normal range, whereas 38 of 61 (62%) in group 2 had a normal score. The EF domain score in group 1 and 2 improved significantly after 1 year of treatment, from 13.6 to 18.9, and 15.1 to 23.9, respectively ( P < 0.01). After the subsequent 4-week wash-out phase, men from both

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Some Characteristics of Nocturnal Penile Tumescence in Elderly Males

Cited by 76 publications

References 0 publications

Temporal Relationship between Nocturnal Erections and Rapid Eye Movement Episodes in Healthy Men

Temporal Relationship between Nocturnal Erections and Rapid Eye Movement Episodes in Healthy Men

Sildenafil improves nocturnal penile erections in organic impotence

Long‐term treatment of erectile dysfunction with a phosphodiesterase‐5 inhibitor and dose optimization based on nocturnal penile tumescence

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