Some Characteristics and Functional Relations of the Electrical Activity of the Primate Hippocampus and a Hypothesis of Hippocampal Function

Crowne, Douglas P.; Radcliffe, Dolores D.

doi:10.1007/978-1-4684-2979-4_6

Cited by 30 publications

(13 citation statements)

References 67 publications

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“…Moreover, Dahl and Winson (1986) speculated about a neuronal gate-control mechanism mediated by supramammillary afferents that may facilitate the information flow in the rat dentate gyrus in a behaviordependent manner. The pathway described in the present study may well be involved in these phenomena and may be a morphological correlate for a powerful control mechanism of hippocampal 8 activity (Crowne and Radcliffe, 1975;Wyss et al, 1979a,b;Bland, 1986;Kitt et al, 1987;Freund and Antal, 1988;Freund, 1989;Stewart and Fox, 1989a,b;Jakab and Leranth, 19951, which has been demonstrated in recent physiological studies (Kocsis and Vertes, 1994).…”

Section: Functional Implicationsmentioning

confidence: 54%

GABAergic neurons in the rat dentate gyrus are innervated by subcortical calretinin-containing afferents

Nitsch

Léránth

1996

J. Comp. Neurol.

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Fibers of supramammillary origin establish putatively excitatory asymmetric synaptic connections with dentate granule cells. The present study was designed to determine whether hippocampal gamma-aminobutyric acid (GABA)-ergic nonprincipal cells are also targets of these calretinin (CR)-containing subcortical afferents. Light and electron microscopic double immunostaining for CR and parvalbumin (PA) or calbindin (CB) were performed in the rat dentate gyrus ipsilateral and contralateral to a unilateral fimbria-fornix transection. GABA-postembedding immunostaining was performed on ultrathin sections of this double-labeled material. Contralateral to the transection, CR-immunoreactive fibers formed multiple large boutons in the inner molecular layer. These fibers also impinged on PA-containing basket cells located adjacent to the granular layer and on CB-immunoreactive hilar neurons. Ipsilateral to the transection, CR-containing fibers in the inner molecular layer and boutons impinging on PA-containing or CB-immunoreactive neurons were absent. Parent cell bodies of extrinsic CR-containing afferents were traced using wheat germ agglutinin-conjugated horseradish peroxidase. Additional CR immunostaining of the subcortical region unveiled retrogradely labeled neurons that were also immunostained for CR only in the supramammillary area and the nucleus reuniens. The latter projection, however, terminates in CA1 and not in the dentate gyrus. Subcortical afferents impinging on dentate nonprincipal cells formed exclusively asymmetric synapses. Postembedding immunostaining demonstrated that CB-containing cells contain GABA, whereas CR-positive axon terminals forming asymmetric synapses are devoid of this labeling. These data indicate that dentate inhibitory neurons receive a putative excitatory input originating from the supramammillary nucleus. Thus, the supramamillo-hippocampal pathway may exert a powerful feed-forward inhibitory control of the signal flow in the rat dentate gyrus.

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Section: Functional Implicationsmentioning

confidence: 54%

GABAergic neurons in the rat dentate gyrus are innervated by subcortical calretinin-containing afferents

Nitsch

Léránth

1996

J. Comp. Neurol.

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“…With respect to the error monitoring view of the ERN, in primates the most reliable method for eliciting hippocampal theta is withholding an expected reward (Crowne and Radcliffe, 1975). Furthermore, hippocampal theta is more prevalent in the early stages of learning, whereas it habituates in the later stages (Pickenhain and Klingberg, 1967).…”

Section: Resultsmentioning

confidence: 99%

Fontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation

LUU

2004

Clinical Neurophysiology

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Objective: The error-related negativity (ERN) is an event-related potential (ERP) peak occurring between 50 and 100 ms after the commission of a speeded motor response that the subject immediately realizes to be in error. The ERN is believed to index brain processes that monitor action outcomes. Our previous analyses of ERP and EEG data suggested that the ERN is dominated by partial phase-locking of intermittent theta-band EEG activity. In this paper, this possibility is further evaluated.Methods: The possibility that the ERN is produced by phase-locking of theta-band EEG activity was examined by analyzing the singletrial EEG traces from a forced-choice speeded response paradigm before and after applying theta-band (4-7 Hz) filtering and by comparing the averaged and single-trial phase-locked (ERP) and non-phase-locked (other) EEG data. Electrical source analyses were used to estimate the brain sources involved in the generation of the ERN.Results: Beginning just before incorrect button presses in a speeded choice response paradigm, midfrontal theta-band activity increased in amplitude and became partially and transiently phase-locked to the subject's motor response, accounting for 57% of ERN peak amplitude. The portion of the theta-EEG activity increase remaining after subtracting the response-locked ERP from each trial was larger and longer lasting after error responses than after correct responses, extending on average 400 ms beyond the ERN peak. Multiple equivalent-dipole source analysis suggested 3 possible equivalent dipole sources of the theta-bandpassed ERN, while the scalp distribution of non-phase-locked theta amplitude suggested the presence of additional frontal theta-EEG sources.Conclusions: These results appear consistent with a body of research that demonstrates a relationship between limbic theta activity and action regulation, including error monitoring and learning.

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“…This relation of the measured ''event-related potential'' to modulation of intrinsic rhythms of corticolimbic electrophysiology further supports comparisons with frustration theory. In both primates and rodents electrophysiological responses to surprising non-reward occur at the theta frequency and may be detected in the hippocampus (Crowne and Radcliffe 1975;Gray 1982). In this regard, human intracranial studies have shown that the ERN can be recorded within the hippocampus (Brá zdil et al 2002).…”

Section: Corticolimbic Control Processesmentioning

confidence: 98%

Neurophysiology of Motivated Learning: Adaptive Mechanisms Underlying Cognitive Bias in Depression

Tucker

Luu

2007

Cogn Ther Res

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Cognitive Behavior Therapy for depression focuses on changing cognitive appraisals of the self and life events. This approach contrasts with behaviorist approaches to clinical disorders, which focused on elementary learning explanations and assumed that cognitive mediation is irrelevant. A better integration of behavioral analysis with cognitive therapy could be facilitated by the theoretical advances in animal learning theory over the last several decades. Animals have been found to respond to events in relation to mental representations of the reward value of those events. The evidence now shows that learning in mammals cannot be explained by passive behaviorist association principles, but requires a theoretical understanding of the animal's hedonic expectancies and its adaptive response to discrepancies from those expectancies. The mechanisms of cognitive representation and information handling that are implied by modern learning theory have presented clear and specific challenges to neurophysiological theories of motivational control of learning and memory. The mechanisms of human motivational control appear to be similar to those of other mammals, suggesting that progress with understanding neurophysiological mechanisms of hedonic evaluation, frustration, and action regulation will soon provide the opportunity for a comprehensive neuropsychological model to guide diagnosis and treatment of depressive disorders.

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Some Characteristics and Functional Relations of the Electrical Activity of the Primate Hippocampus and a Hypothesis of Hippocampal Function

Cited by 30 publications

References 67 publications

GABAergic neurons in the rat dentate gyrus are innervated by subcortical calretinin-containing afferents

GABAergic neurons in the rat dentate gyrus are innervated by subcortical calretinin-containing afferents

Fontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation

Neurophysiology of Motivated Learning: Adaptive Mechanisms Underlying Cognitive Bias in Depression

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