Some central pharmacological effects of (+)- and (−)-oxaprotiline

J, Maj; Rogóż, Z; Skuza, G; Sowińska, H

doi:10.1007/bf01257078

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…An example of a nonmonoamine approach for the treatment of depression is based on modulation of the glutamatergic system, particularly via N-methyl-D-aspartate (NMDA) receptors. [5][6][7] A number of researchers have looked at the role of the glutamatergic system in depression and there is now evidence that this mood disorder is associated, at least partly, with increased levels of extracellular glutamate. 8 Clinical and preclinical studies increasingly support the glutamate-based hypothesis of depression by showing that ketamine, an NMDA receptor antagonist, elicits rapid antidepressant effects, [9][10][11] encouraging the assumption that modulation of glutamatergic neurotransmission might be a promising strategy for nextgeneration fast-acting antidepressants.…”

Section: Depressionmentioning

confidence: 99%

Nutritional strategies for dealing with depression

2013

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Depression is a highly recurrent and debilitating psychiatric disorder associated with multicausal origins. Impairments in the monoaminergic transmission, increased glutamatergic excitotoxicity, neuroinflammation, oxidative stress and deficits in neurotrophic factors are the main hypothesis raised in order to explain the etiological basis of depression. Although the current antidepressant therapy usually alleviates symptoms and prevents recurrence of episodes, the delay in the onset of the therapeutic effect and the refractory or intolerant responses exhibited by a large number of patients are the main drawbacks of the current therapy. For these reasons, several studies have dealt with the investigation of alternative therapeutic approaches or adjunctive strategies which could improve clinical outcomes. One potential adjunctive treatment with conventional antidepressants involves the use of nutraceuticals (a food, a part of a food, a vitamin, a mineral, or a herb that provides health benefits). In this review, we will focus on the main nutrients, phytochemicals and food that have been shown to have beneficial effects against depression.

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Section: Depressionmentioning

confidence: 99%

Nutritional strategies for dealing with depression

2013

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Atypische Antidepressiva

Laux¹,

Delini‐Stula²,

Breyer-Pfaff³

et al. 1993

Neuro-Psychopharmaka

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Oxaprotiline enantiomers stimulate ACTH and corticosterone secretion in the rat

Przegaliński

Budziszewska

Grochmal

1991

J. Neural Transmission

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The effect of oxaprotiline (OXA) enantiomers--of which (+)-OXA inhibits noradrenaline (NA) uptake, whereas (-)-OXA does not--on the secretion of adrenocorticotropin hormone (ACTH) and corticosterone was studied in rats. Both enantiomers dose-dependently and with a similar potency increased the plasma level of ACTH and corticosterone, the effect of (-)-OXA on corticosterone being of a longer duration. The stimulation of ACTH secretion and the inability of (+)- and (-)-OXA to increase the plasma corticosterone concentration in animals pretreated with dexamethasone indicate that secretion of the latter hormone results from the action of the enantiomers at a level superior to the adrenal cortex, i.e. the hypothalamus/pituitary. The corticosterone response to (+)- or (-)-OXA was not modified in rats with a selective lesion of NA nerve endings induced by the neurotoxin DSP-4, nor was it affected by the selective alpha 1-antagonist prazosin, the selective alpha 2-antagonist yohimbine, the mixed alpha 1/alpha 2-antagonist phentolamine, the selective dopamine (D2) receptor antagonist sulpiride and the non-selective 5-hydroxytryptamine (5-HT) receptor antagonist metergoline. These results indicate that neither the NA system nor D2 and 5-HT receptors are involved in the hormonal response to the OXA enantiomers. Although the (+)- and (-)-OXA-induced stimulation of corticosterone secretion was not antagonized by diazepam, ipsapirone, naloxone, or propranolol, it cannot be excluded that both these enantiomers act as non-specific stressors.

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Some central pharmacological effects of (+)- and (−)-oxaprotiline

Cited by 6 publications

References 16 publications

Nutritional strategies for dealing with depression

Nutritional strategies for dealing with depression

Atypische Antidepressiva

Oxaprotiline enantiomers stimulate ACTH and corticosterone secretion in the rat

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